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dc.contributor.authorDiwanji, Neha
dc.contributor.authorBergmann, Andreas
dc.date2022-08-11T08:08:56.000
dc.date.accessioned2022-08-23T16:13:04Z
dc.date.available2022-08-23T16:13:04Z
dc.date.issued2019-09-14
dc.date.submitted2021-07-06
dc.identifier.citation<p>Diwanji N, Bergmann A. Two Sides of the Same Coin - Compensatory Proliferation in Regeneration and Cancer. Adv Exp Med Biol. 2019;1167:65-85. doi: 10.1007/978-3-030-23629-8_4. PMID: 31520349.</p>
dc.identifier.doi10.1007/978-3-030-23629-8_4
dc.identifier.pmid31520349
dc.identifier.urihttp://hdl.handle.net/20.500.14038/33532
dc.description.abstractApoptosis has long been regarded as a tumor suppressor mechanism and evasion from apoptosis is considered to be one hallmark of cancer. However, this principle is not always consistent with clinical data which often illustrate a correlation between apoptosis and poor prognosis. Work in the last 15 years has provided an explanation for this apparent paradox. Apoptotic cells communicate with their environment and can produce signals which promote compensatory proliferation of surviving cells. This behavior of apoptotic cells is important for tissue regeneration in several model organisms, ranging from hydra to mammals. However, it may also play an important feature for tumorigenesis and tumor relapse. Several distinct forms of apoptosis-induced compensatory proliferation (AiP) have been identified, many of which involve reactive oxygen species (ROS) and immune cells. One type of AiP, "undead" AiP, in which apoptotic cells are kept in an immortalized state and continuously divide, may have particular relevance for tumorigenesis. Furthermore, given that chemo- and radiotherapy often aim to kill tumor cells, an improved understanding of the effects of apoptotic cells on the tumor and the tumor environment is of critical importance for the well-being of the patient. In this review, we summarize the current knowledge of AiP and focus our attention on recent findings obtained in Drosophila and other model organisms, and relate them to tumorigenesis.
dc.language.isoen_US
dc.relation<p><a href="https://pubmed.ncbi.nlm.nih.gov/31520349/" target="_blank" title="view chapter in PubMed">Link to chapter in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.1007/978-3-030-23629-8_4
dc.subjectApoptosis-induced proliferation
dc.subjectCaspases
dc.subjectReactive oxygen species
dc.subjectMacrophages
dc.subjectDrosophila
dc.subjectCancer Biology
dc.titleTwo sides of the same coin – compensatory proliferation in regeneration and cancer
dc.typeBook Chapter
dc.source.booktitleThe Drosophila Model in Cancer. Advances in Experimental Medicine and Biology
dc.source.volume1167
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=3080&amp;context=gsbs_sp&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/2056
dc.legacy.embargo2021-07-06T00:00:00-07:00
dc.identifier.contextkey23701267
refterms.dateFOA2022-08-23T16:13:04Z
html.description.abstract<p>Apoptosis has long been regarded as a tumor suppressor mechanism and evasion from apoptosis is considered to be one hallmark of cancer. However, this principle is not always consistent with clinical data which often illustrate a correlation between apoptosis and poor prognosis. Work in the last 15 years has provided an explanation for this apparent paradox. Apoptotic cells communicate with their environment and can produce signals which promote compensatory proliferation of surviving cells. This behavior of apoptotic cells is important for tissue regeneration in several model organisms, ranging from hydra to mammals. However, it may also play an important feature for tumorigenesis and tumor relapse. Several distinct forms of apoptosis-induced compensatory proliferation (AiP) have been identified, many of which involve reactive oxygen species (ROS) and immune cells. One type of AiP, "undead" AiP, in which apoptotic cells are kept in an immortalized state and continuously divide, may have particular relevance for tumorigenesis. Furthermore, given that chemo- and radiotherapy often aim to kill tumor cells, an improved understanding of the effects of apoptotic cells on the tumor and the tumor environment is of critical importance for the well-being of the patient. In this review, we summarize the current knowledge of AiP and focus our attention on recent findings obtained in Drosophila and other model organisms, and relate them to tumorigenesis.</p>
dc.identifier.submissionpathgsbs_sp/2056
dc.contributor.departmentMolecular, Cell and Cancer Biology
dc.source.pages65-85
dc.contributor.studentNeha Diwanji


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