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dc.contributor.authorCielinski, Matthew J.
dc.contributor.authorJolie, M.
dc.contributor.authorWise, Gary E.
dc.contributor.authorMarks, Sandy C.
dc.date2022-08-11T08:08:56.000
dc.date.accessioned2022-08-23T16:13:09Z
dc.date.available2022-08-23T16:13:09Z
dc.date.issued1995-01-01
dc.date.submitted2008-08-26
dc.identifier.citation<p>Connect Tissue Res. 1995;32(1-4):165-9.</p>
dc.identifier.issn0300-8207 (Print)
dc.identifier.doi10.3109/03008209509013720
dc.identifier.pmid7554913
dc.identifier.urihttp://hdl.handle.net/20.500.14038/33555
dc.description.abstractBoth epidermal growth factor (EGF) and colony-stimulating factor-1 (CSF-1) have been shown to accelerate eruption of teeth in rodents. We compared the effects of neonatal injections of EGF (1 micrograms/g body weight) and CSF-1 (10(6) units) alone or together on the eruption of incisors and first molars. EGF accelerated the eruption of incisors with no significant effect on first molars. CSF-1, in contrast, accelerated molar eruption more than incisor eruption. CSF-1, but not EGF, increased the numbers of mononuclear cells in the dental follicle and osteoclasts on adjacent alveolar bone surfaces around the first molar and produced enhanced resorption of crypt surfaces as revealed by scanning electron microscopy. These data suggest that during eruption rodent incisors and molars may preferentially respond to different molecular regulators.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7554913&dopt=Abstract ">Link to article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.3109/03008209509013720
dc.subjectAlveolar Process; Animals; Animals, Newborn; Bone Resorption; Cell Count; Dental Sac; Drug Combinations; Epidermal Growth Factor; Incisor; Leukocyte Count; Leukocytes, Mononuclear; Macrophage Colony-Stimulating Factor; Microscopy, Electron, Scanning; Molar; Osteoclasts; Rats; Tooth Eruption
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleThe contrasting effects of colony-stimulating factor-1 and epidermal growth factor on tooth eruption in the rat
dc.typeJournal Article
dc.source.journaltitleConnective tissue research
dc.source.volume32
dc.source.issue1-4
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/227
dc.identifier.contextkey604120
html.description.abstract<p>Both epidermal growth factor (EGF) and colony-stimulating factor-1 (CSF-1) have been shown to accelerate eruption of teeth in rodents. We compared the effects of neonatal injections of EGF (1 micrograms/g body weight) and CSF-1 (10(6) units) alone or together on the eruption of incisors and first molars. EGF accelerated the eruption of incisors with no significant effect on first molars. CSF-1, in contrast, accelerated molar eruption more than incisor eruption. CSF-1, but not EGF, increased the numbers of mononuclear cells in the dental follicle and osteoclasts on adjacent alveolar bone surfaces around the first molar and produced enhanced resorption of crypt surfaces as revealed by scanning electron microscopy. These data suggest that during eruption rodent incisors and molars may preferentially respond to different molecular regulators.</p>
dc.identifier.submissionpathgsbs_sp/227
dc.contributor.departmentDepartment of Anatomy
dc.contributor.departmentDepartment of Cell Biology
dc.contributor.departmentGraduate School of Biomedical Sciences
dc.source.pages165-9


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