A peptidyl transferase ribozyme capable of combinatorial peptide synthesis
| dc.contributor.author | Cui, Zhiyong | |
| dc.contributor.author | Sun, Lele | |
| dc.contributor.author | Zhang, Biliang | |
| dc.date | 2022-08-11T08:08:56.000 | |
| dc.date.accessioned | 2022-08-23T16:13:17Z | |
| dc.date.available | 2022-08-23T16:13:17Z | |
| dc.date.issued | 2004-02-26 | |
| dc.date.submitted | 2008-08-29 | |
| dc.identifier.citation | Bioorg Med Chem. 2004 Mar 1;12(5):927-33. <a href="http://dx.doi.org/10.1016/j.bmc.2003.12.018">Link to article on publisher's site</a> | |
| dc.identifier.issn | 0968-0896 (Print) | |
| dc.identifier.doi | 10.1016/j.bmc.2003.12.018 | |
| dc.identifier.pmid | 14980605 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14038/33587 | |
| dc.description.abstract | The formation of peptide bonds is a key step in both the chemical and biological synthesis of peptides. The ribozyme can use a wide range of amino acids as its substrate for the dipeptide synthesis. A library containing 29 peptides whose synthesis was catalyzed by this unique ribozyme was analyzed by mass spectrometry. These results implicate that ribozyme may have potential application in the peptide synthesis. | |
| dc.language.iso | en_US | |
| dc.relation | <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14980605&dopt=Abstract">Link to article in PubMed</a> | |
| dc.relation.url | http://dx.doi.org/10.1016/j.bmc.2003.12.018 | |
| dc.subject | *Combinatorial Chemistry Techniques; Dipeptides; Mass Spectrometry; Peptide Library; Peptidyl Transferases; RNA, Catalytic | |
| dc.subject | Life Sciences | |
| dc.subject | Medicine and Health Sciences | |
| dc.title | A peptidyl transferase ribozyme capable of combinatorial peptide synthesis | |
| dc.type | Journal Article | |
| dc.source.journaltitle | Bioorganic and medicinal chemistry | |
| dc.source.volume | 12 | |
| dc.source.issue | 5 | |
| dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/gsbs_sp/257 | |
| dc.identifier.contextkey | 610000 | |
| html.description.abstract | <p>The formation of peptide bonds is a key step in both the chemical and biological synthesis of peptides. The ribozyme can use a wide range of amino acids as its substrate for the dipeptide synthesis. A library containing 29 peptides whose synthesis was catalyzed by this unique ribozyme was analyzed by mass spectrometry. These results implicate that ribozyme may have potential application in the peptide synthesis.</p> | |
| dc.identifier.submissionpath | gsbs_sp/257 | |
| dc.contributor.department | Program in Molecular Medicine | |
| dc.contributor.department | Graduate School of Biomedical Sciences | |
| dc.source.pages | 927-33 |
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