Blockade of CD40-CD154 interferes with human T cell engraftment in scid mice
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Authors
Foy, Teresa M.McIlraith, Melissa
Masters, Sally R.
Dunn, Jonathan J.
Rossini, Aldo A.
Shultz, Leonard D.
Hesselton, RuthAnn M.
Wagar, Eric James
Lipsky, Peter E.
Noelle, Randolph J.
Greiner, Dale L.
UMass Chan Affiliations
Department of Medicine, Division of DiabetesGraduate School of Biomedical Sciences
Document Type
Journal ArticlePublication Date
1998-03-07Keywords
Adult; Animals; Antibodies, Monoclonal; Antigens, CD; Antigens, CD40; Antigens, CD80; Antigens, CD86; B-Lymphocytes; CD40 Ligand; Cell Differentiation; Cell Transplantation; Graft Survival; Humans; Ligands; Lymphocyte Activation; Membrane Glycoproteins; Mice; Mice, SCID; T-Lymphocytes; Tetanus Toxoid; Transplantation, HeterologousLife Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Antibodies to the ligand for CD40 (CD154) have been shown to exert profound effects on the development of cell-mediated immune responses in mice. The present study shows that an antibody to human CD154 (hCD40L) inhibits in vivo Tetanus toxoid (TT) specific secondary antibody responses in hu-PBL-scid mice, as well as the expansion of xenoreactive human T cells in the scid mice. A possible cause for the reduced expansion of xenoreactive, human T cells, was the decreased expression of murine B7.1 and B7.2 caused by the administration of anti-hCD40L. Therefore, it may be that defective maturation of murine antigen-presenting cells impeded the priming and expansion of human xenoreactive T cells.Source
Cell Transplant. 1998 Jan-Feb;7(1):25-35.
DOI
10.1016/S0963-6897(97)00113-9Permanent Link to this Item
http://hdl.handle.net/20.500.14038/33638PubMed ID
9489760Related Resources
ae974a485f413a2113503eed53cd6c53
10.1016/S0963-6897(97)00113-9