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Blockade of CD40-CD154 interferes with human T cell engraftment in scid mice

dc.contributor.authorFoy, Teresa M.
dc.contributor.authorMcIlraith, Melissa
dc.contributor.authorMasters, Sally R.
dc.contributor.authorDunn, Jonathan J.
dc.contributor.authorRossini, Aldo A.
dc.contributor.authorShultz, Leonard D.
dc.contributor.authorHesselton, RuthAnn M.
dc.contributor.authorWagar, Eric James
dc.contributor.authorLipsky, Peter E.
dc.contributor.authorNoelle, Randolph J.
dc.contributor.authorGreiner, Dale L.
dc.date2022-08-11T08:08:57.000
dc.date.accessioned2022-08-23T16:13:30Z
dc.date.available2022-08-23T16:13:30Z
dc.date.issued1998-03-07
dc.date.submitted2008-09-03
dc.identifier.citation<p>Cell Transplant. 1998 Jan-Feb;7(1):25-35.</p>
dc.identifier.issn0963-6897 (Print)
dc.identifier.doi10.1016/S0963-6897(97)00113-9
dc.identifier.pmid9489760
dc.identifier.urihttp://hdl.handle.net/20.500.14038/33638
dc.description.abstractAntibodies to the ligand for CD40 (CD154) have been shown to exert profound effects on the development of cell-mediated immune responses in mice. The present study shows that an antibody to human CD154 (hCD40L) inhibits in vivo Tetanus toxoid (TT) specific secondary antibody responses in hu-PBL-scid mice, as well as the expansion of xenoreactive human T cells in the scid mice. A possible cause for the reduced expansion of xenoreactive, human T cells, was the decreased expression of murine B7.1 and B7.2 caused by the administration of anti-hCD40L. Therefore, it may be that defective maturation of murine antigen-presenting cells impeded the priming and expansion of human xenoreactive T cells.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9489760&dopt=Abstract ">Link to article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.1016/S0963-6897(97)00113-9
dc.titleBlockade of CD40-CD154 interferes with human T cell engraftment in scid mice
dc.typeJournal Article
dc.source.journaltitleCell transplantation
dc.source.volume7
dc.source.issue1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/306
dc.identifier.contextkey616282
html.description.abstract<p>Antibodies to the ligand for CD40 (CD154) have been shown to exert profound effects on the development of cell-mediated immune responses in mice. The present study shows that an antibody to human CD154 (hCD40L) inhibits in vivo Tetanus toxoid (TT) specific secondary antibody responses in hu-PBL-scid mice, as well as the expansion of xenoreactive human T cells in the scid mice. A possible cause for the reduced expansion of xenoreactive, human T cells, was the decreased expression of murine B7.1 and B7.2 caused by the administration of anti-hCD40L. Therefore, it may be that defective maturation of murine antigen-presenting cells impeded the priming and expansion of human xenoreactive T cells.</p>
dc.identifier.submissionpathgsbs_sp/306
dc.contributor.departmentDepartment of Medicine, Division of Diabetes
dc.contributor.departmentMorningside Graduate School of Biomedical Sciences
dc.source.pages25-35


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