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dc.contributor.authorPotts, John T.
dc.contributor.authorGardella, Thomas James
dc.date2022-08-11T08:08:57.000
dc.date.accessioned2022-08-23T16:13:41Z
dc.date.available2022-08-23T16:13:41Z
dc.date.issued2007-12-07
dc.date.submitted2008-09-08
dc.identifier.citationAnn N Y Acad Sci. 2007 Nov;1117:196-208. <a href="http://dx.doi.org/10.1196/annals.1402.088">Link to article on publisher's site</a>
dc.identifier.issn0077-8923 (Print)
dc.identifier.doi10.1196/annals.1402.088
dc.identifier.pmid18056044
dc.identifier.urihttp://hdl.handle.net/20.500.14038/33682
dc.description.abstractWith the advent of advances in chemical and molecular biology, the structure of parathyroid hormone (PTH); the related protein, parathyroid-related protein (PTHrP); and their principal receptor (PTH/PTHrP receptor [PTHR1]) were established over recent decades. Tests with purified hormonal peptide in humans led to the surprising, even paradoxical, finding that PTH can be used pharmacologically to build bone, providing a dramatic therapeutic impact on osteoporosis. These developments plus recent insights into previously unappreciated ligand-receptor conformations that cause prolonged biological activation have stimulated the field of calcium and bone biology and posed new questions about the role of PTH and PTHrP as well as possible new directions in the therapy of osteoporosis and calcium-deficit states.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=18056044&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1196/annals.1402.088
dc.subjectAmino Acid Sequence; Animals; Biology; Cattle; Evolution, Molecular; Humans; Ligands; Models, Biological; Molecular Conformation; Molecular Sequence Data; Osteoporosis; Parathyroid Glands; Parathyroid Hormone; Receptor, Parathyroid Hormone, Type 1
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleProgress, paradox, and potential: parathyroid hormone research over five decades
dc.typeJournal Article
dc.source.journaltitleAnnals of the New York Academy of Sciences
dc.source.volume1117
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/347
dc.identifier.contextkey622932
html.description.abstract<p>With the advent of advances in chemical and molecular biology, the structure of parathyroid hormone (PTH); the related protein, parathyroid-related protein (PTHrP); and their principal receptor (PTH/PTHrP receptor [PTHR1]) were established over recent decades. Tests with purified hormonal peptide in humans led to the surprising, even paradoxical, finding that PTH can be used pharmacologically to build bone, providing a dramatic therapeutic impact on osteoporosis. These developments plus recent insights into previously unappreciated ligand-receptor conformations that cause prolonged biological activation have stimulated the field of calcium and bone biology and posed new questions about the role of PTH and PTHrP as well as possible new directions in the therapy of osteoporosis and calcium-deficit states.</p>
dc.identifier.submissionpathgsbs_sp/347
dc.contributor.departmentGraduate School of Biomedical Sciences
dc.source.pages196-208


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