Verification of enhancement of the CSF space, not parenchyma, in acute stroke patients with early blood-brain barrier disruption
UMass Chan Affiliations
Graduate School of Biomedical SciencesDocument Type
Journal ArticlePublication Date
2007-12-20Keywords
Acute Disease; Aged; Blood-Brain Barrier; Cerebrospinal Fluid; Contrast Media; Extracellular Space; Gadolinium DTPA; Humans; Magnetic Resonance Imaging; Models, Neurological; Retrospective Studies; StrokeLife Sciences
Medicine and Health Sciences
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Show full item recordAbstract
Enhancement on post-contrast fluid-attenuated inversion recovery (FLAIR) images after acute stroke has been attributed to early blood-brain barrier disruption. Using an estimate of parenchymal volume fraction and the apparent diffusion coefficient (ADC), we investigated the relative contributions of cerebral spinal fluid (CSF) and parenchyma to enhancement seen on postcontrast FLAIR. Enhancing regions were found to have low parenchymal volume fractions and high ADC values, approaching that of pure CSF. These findings suggest that contrast enhancement on FLAIR occurs predominately in the CSF space, not parenchyma.Source
J Cereb Blood Flow Metab. 2008 May;28(5):882-6. Epub 2007 Dec 19. Link to article on publisher's siteDOI
10.1038/sj.jcbfm.9600598Permanent Link to this Item
http://hdl.handle.net/20.500.14038/33686PubMed ID
18091756Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1038/sj.jcbfm.9600598