Show simple item record

Verification of enhancement of the CSF space, not parenchyma, in acute stroke patients with early blood-brain barrier disruption

dc.contributor.authorHenning, Erica C.
dc.contributor.authorLatour, Lawrence L.
dc.contributor.authorWarach, Steven
dc.date2022-08-11T08:08:57.000
dc.date.accessioned2022-08-23T16:13:42Z
dc.date.available2022-08-23T16:13:42Z
dc.date.issued2007-12-20
dc.date.submitted2008-09-08
dc.identifier.citationJ Cereb Blood Flow Metab. 2008 May;28(5):882-6. Epub 2007 Dec 19. <a href="http://dx.doi.org/10.1038/sj.jcbfm.9600598">Link to article on publisher's site</a>
dc.identifier.issn0271-678X (Print)
dc.identifier.doi10.1038/sj.jcbfm.9600598
dc.identifier.pmid18091756
dc.identifier.urihttp://hdl.handle.net/20.500.14038/33686
dc.description.abstractEnhancement on post-contrast fluid-attenuated inversion recovery (FLAIR) images after acute stroke has been attributed to early blood-brain barrier disruption. Using an estimate of parenchymal volume fraction and the apparent diffusion coefficient (ADC), we investigated the relative contributions of cerebral spinal fluid (CSF) and parenchyma to enhancement seen on postcontrast FLAIR. Enhancing regions were found to have low parenchymal volume fractions and high ADC values, approaching that of pure CSF. These findings suggest that contrast enhancement on FLAIR occurs predominately in the CSF space, not parenchyma.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=18091756&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1038/sj.jcbfm.9600598
dc.subjectAcute Disease; Aged; Blood-Brain Barrier; Cerebrospinal Fluid; Contrast Media; Extracellular Space; Gadolinium DTPA; Humans; Magnetic Resonance Imaging; Models, Neurological; Retrospective Studies; Stroke
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleVerification of enhancement of the CSF space, not parenchyma, in acute stroke patients with early blood-brain barrier disruption
dc.typeJournal Article
dc.source.journaltitleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
dc.source.volume28
dc.source.issue5
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/351
dc.identifier.contextkey622936
html.description.abstract<p>Enhancement on post-contrast fluid-attenuated inversion recovery (FLAIR) images after acute stroke has been attributed to early blood-brain barrier disruption. Using an estimate of parenchymal volume fraction and the apparent diffusion coefficient (ADC), we investigated the relative contributions of cerebral spinal fluid (CSF) and parenchyma to enhancement seen on postcontrast FLAIR. Enhancing regions were found to have low parenchymal volume fractions and high ADC values, approaching that of pure CSF. These findings suggest that contrast enhancement on FLAIR occurs predominately in the CSF space, not parenchyma.</p>
dc.identifier.submissionpathgsbs_sp/351
dc.contributor.departmentGraduate School of Biomedical Sciences
dc.source.pages882-6


This item appears in the following Collection(s)

Show simple item record