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dc.contributor.authorFreeman, Marc R.
dc.contributor.authorDoherty, Johnna E.
dc.date2022-08-11T08:08:57.000
dc.date.accessioned2022-08-23T16:13:43Z
dc.date.available2022-08-23T16:13:43Z
dc.date.issued2006-02-27
dc.date.submitted2008-09-10
dc.identifier.citationTrends Neurosci. 2006 Feb;29(2):82-90. Epub 2006 Jan 10. <a href="http://dx.doi.org/10.1016/j.tins.2005.12.002">Link to article on publisher's site</a>
dc.identifier.issn0166-2236 (Print)
dc.identifier.doi10.1016/j.tins.2005.12.002
dc.identifier.pmid16377000
dc.identifier.urihttp://hdl.handle.net/20.500.14038/33690
dc.description.abstractGlia are the most abundant cell type in the mammalian nervous system and they have vital roles in neural development, function and health. However our understanding of the biology of glia is in its infancy. How do glia develop and interact with neurons? How diverse are glial populations? What are the primary functions of glia in the mature nervous system? These questions can be addressed incisively in the Drosophila nervous system--this contains relatively few glia, which are well-defined histologically and amenable to powerful molecular-genetic analyses. Here, we highlight several developmental, morphological and functional similarities between Drosophila and vertebrate glia. The striking parallels that emerge from this comparison argue that invertebrate model organisms such as Drosophila have excellent potential to add to our understanding of fundamental aspects of glial biology.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16377000&dopt=Abstract">Link to article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/j.tins.2005.12.002
dc.subjectAnimals; Drosophila; Humans; Nervous System Physiology; Neuroglia; Neurons; Vertebrates
dc.subjectNeuroscience and Neurobiology
dc.titleGlial cell biology in Drosophila and vertebrates
dc.typeJournal Article
dc.source.journaltitleTrends in neurosciences
dc.source.volume29
dc.source.issue2
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/355
dc.identifier.contextkey625981
html.description.abstract<p>Glia are the most abundant cell type in the mammalian nervous system and they have vital roles in neural development, function and health. However our understanding of the biology of glia is in its infancy. How do glia develop and interact with neurons? How diverse are glial populations? What are the primary functions of glia in the mature nervous system? These questions can be addressed incisively in the Drosophila nervous system--this contains relatively few glia, which are well-defined histologically and amenable to powerful molecular-genetic analyses. Here, we highlight several developmental, morphological and functional similarities between Drosophila and vertebrate glia. The striking parallels that emerge from this comparison argue that invertebrate model organisms such as Drosophila have excellent potential to add to our understanding of fundamental aspects of glial biology.</p>
dc.identifier.submissionpathgsbs_sp/355
dc.contributor.departmentGraduate School of Biomedical Sciences, Neuroscience Program
dc.contributor.departmentFreeman Lab
dc.contributor.departmentNeurobiology
dc.source.pages82-90
dc.contributor.studentJohnna Doherty
dc.description.thesisprogramNeuroscience


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