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    Bystander target cell lysis and cytokine production by dengue virus-specific human CD4(+) cytotoxic T-lymphocyte clones

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    Authors
    Gagnon, Susan J.
    Ennis, Francis A.
    Rothman, Alan L.
    UMass Chan Affiliations
    Center for Infectious Disease and Vaccine Research
    Graduate School of Biomedical Sciences
    Document Type
    Journal Article
    Publication Date
    1999-04-10
    Keywords
    Antigen Presentation; Antigens, CD95; CD4-Positive T-Lymphocytes; Cytotoxicity, Immunologic; Dengue Virus; Fas Ligand Protein; Humans; Interferon Type II; Lymphocyte Activation; Lymphotoxin-alpha; Membrane Glycoproteins; T-Lymphocytes, Cytotoxic; Tumor Necrosis Factor-alpha
    Life Sciences
    Medicine and Health Sciences
    
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC104137/
    Abstract
    Dengue hemorrhagic fever, the severe form of dengue virus infection, is believed to be an immunopathological response to a secondary infection with a heterologous serotype of dengue virus. Dengue virus capsid protein-specific CD4(+) cytotoxic T-lymphocyte (CTL) clones were shown to be capable of mediating bystander lysis of non-antigen-presenting target cells. After activation by anti-CD3 or in the presence of unlabeled antigen-presenting target cells, these clones could lyse both Jurkat cells and HepG2 cells as bystander targets. Lysis of HepG2 cells suggests a potential role for CD4(+) CTL in the liver involvement observed during dengue virus infection. Three CD4(+) CTL clones were demonstrated to lyse cognate, antigen-presenting target cells by a mechanism that primarily involves perforin, while bystander lysis occurred through Fas/Fas ligand interactions. In contrast, one clone used a Fas/Fas ligand mechanism to lyse both cognate and bystander targets. Cytokine production by the CTL clones was also examined. In response to stimulation with D2 antigen, CD4(+) T-cell clones produced gamma interferon, tumor necrosis factor alpha (TNF-alpha) and TNF-beta. The data suggest that CD4(+) CTL clones may contribute to the immunopathology observed upon secondary dengue virus infections through direct cytolysis and/or cytokine production.
    Source

    J Virol. 1999 May;73(5):3623-9.

    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/33698
    PubMed ID
    10196254
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