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    Specific Drosophila Dscam juxtamembrane variants control dendritic elaboration and axonal arborization

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    Authors
    Shi, Lei
    Yu, Hung-Hsiang
    Yang, Jacob S.
    Lee, Tzumin
    Student Authors
    Lei Shi; Jacob Yang
    UMass Chan Affiliations
    Graduate School of Biomedical Sciences, Neuroscience Program
    Lee Lab
    Neurobiology
    Document Type
    Journal Article
    Publication Date
    2007-06-22
    Keywords
    Animals; Animals, Genetically Modified; Axons; Dendrites; Drosophila; Drosophila Proteins; Membrane Proteins; Morphogenesis; Neural Cell Adhesion Molecules; Protein Isoforms; Variation (Genetics)
    Neuroscience and Neurobiology
    
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    Abstract
    Drosophila Dscam isoforms are derived from two alternative transmembrane/juxtamembrane domains (TMs) in addition to thousands of ectodomain variants. Using a microRNA-based RNA interference technology, we selectively knocked down different subsets of Dscams containing either the exon 17.1- or exon 17.2-encoding TM. Eliminating Dscam[TM1] reduced Dscam expression but minimally affected postembryonic axonal morphogenesis. In contrast, depleting Dscam[TM2] blocked axon arborization. Further removal of Dscam[TM1] enhanced the loss-of-Dscam[TM2] axonal phenotypes. However, Dscam[TM1] primarily regulates dendritic development, as evidenced by the observations that removing Dscam[TM1] alone impeded elaboration of dendrites and that transgenic Dscam[TM1], but not Dscam[TM2], effectively rescued Dscam mutant dendritic phenotypes in mosaic organisms. These distinct Dscam functions can be attributed to the juxtamembrane regions of TMs that govern dendritic versus axonal targeting of Dscam as well. Together, we suggest that specific Drosophila Dscam juxtamembrane variants control dendritic elaboration and axonal arborization.
    Source
    J Neurosci. 2007 Jun 20;27(25):6723-8. Link to article on publisher's site
    DOI
    10.1523/JNEUROSCI.1517-07.2007
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/33776
    PubMed ID
    17581959
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1523/JNEUROSCI.1517-07.2007
    Scopus Count
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    Neurobiology Student Publications
    Morningside Graduate School of Biomedical Sciences Scholarly Publications
    Neurobiology Faculty Publications

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