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    Sequential use of mushroom body neuron subsets during drosophila odor memory processing

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    Authors
    Krashes, Michael Jonathan
    Keene, Alex Carl
    Leung, Benjamin M.
    Armstrong, J. Douglas
    Waddell, Scott
    Student Authors
    Michael Krashes
    Alex Keene
    Academic Program
    Neuroscience
    UMass Chan Affiliations
    Graduate School of Biomedical Sciences, Neuroscience Program
    Waddell Lab
    Neurobiology
    Document Type
    Journal Article
    Publication Date
    2007-01-02
    Keywords
    Animals; Animals, Genetically Modified; Avoidance Learning; Drosophila; Electric Stimulation; Gene Expression Regulation, Developmental; Memory; Mushroom Bodies; Mutation; Nerve Net; Neural Pathways; Neurons; *Odors; Smell; Synaptic Transmission
    Neuroscience and Neurobiology
    
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    Link to Full Text
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828290/
    Abstract
    Drosophila mushroom bodies (MB) are bilaterally symmetric multilobed brain structures required for olfactory memory. Previous studies suggested that neurotransmission from MB neurons is only required for memory retrieval. Our unexpected observation that Dorsal Paired Medial (DPM) neurons, which project only to MB neurons, are required during memory storage but not during acquisition or retrieval, led us to revisit the role of MB neurons in memory processing. We show that neurotransmission from the alpha'beta' subset of MB neurons is required to acquire and stabilize aversive and appetitive odor memory, but is dispensable during memory retrieval. In contrast, neurotransmission from MB alphabeta neurons is only required for memory retrieval. These data suggest a dynamic requirement for the different subsets of MB neurons in memory and are consistent with the notion that recurrent activity in an MB alpha'beta' neuron-DPM neuron loop is required to stabilize memories formed in the MB alphabeta neurons.
    Source
    Neuron. 2007 Jan 4;53(1):103-15. Link to article on publisher's site
    DOI
    10.1016/j.neuron.2006.11.021
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/33855
    PubMed ID
    17196534
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.neuron.2006.11.021
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    Morningside GSBS Scholarly Publications
    Neurobiology Student Publications
    Neurobiology Faculty Publications

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