Sequential use of mushroom body neuron subsets during drosophila odor memory processing
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Authors
Krashes, Michael JonathanKeene, Alex Carl
Leung, Benjamin M.
Armstrong, J. Douglas
Waddell, Scott
Student Authors
Michael Krashes; Alex KeeneUMass Chan Affiliations
Graduate School of Biomedical Sciences, Neuroscience ProgramWaddell Lab
Neurobiology
Document Type
Journal ArticlePublication Date
2007-01-02Keywords
Animals; Animals, Genetically Modified; Avoidance Learning; Drosophila; Electric Stimulation; Gene Expression Regulation, Developmental; Memory; Mushroom Bodies; Mutation; Nerve Net; Neural Pathways; Neurons; *Odors; Smell; Synaptic TransmissionNeuroscience and Neurobiology
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Show full item recordAbstract
Drosophila mushroom bodies (MB) are bilaterally symmetric multilobed brain structures required for olfactory memory. Previous studies suggested that neurotransmission from MB neurons is only required for memory retrieval. Our unexpected observation that Dorsal Paired Medial (DPM) neurons, which project only to MB neurons, are required during memory storage but not during acquisition or retrieval, led us to revisit the role of MB neurons in memory processing. We show that neurotransmission from the alpha'beta' subset of MB neurons is required to acquire and stabilize aversive and appetitive odor memory, but is dispensable during memory retrieval. In contrast, neurotransmission from MB alphabeta neurons is only required for memory retrieval. These data suggest a dynamic requirement for the different subsets of MB neurons in memory and are consistent with the notion that recurrent activity in an MB alpha'beta' neuron-DPM neuron loop is required to stabilize memories formed in the MB alphabeta neurons.Source
Neuron. 2007 Jan 4;53(1):103-15. Link to article on publisher's siteDOI
10.1016/j.neuron.2006.11.021Permanent Link to this Item
http://hdl.handle.net/20.500.14038/33855PubMed ID
17196534Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.neuron.2006.11.021