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dc.contributor.authorIsacson, Ole
dc.contributor.authorDeacon, Terrence W.
dc.contributor.authorPakzaban, Peyman
dc.contributor.authorGalpern, Wendy R.
dc.contributor.authorDinsmore, Jonathan H.
dc.contributor.authorBurns, Lindsay H.
dc.date2022-08-11T08:08:59.000
dc.date.accessioned2022-08-23T16:14:38Z
dc.date.available2022-08-23T16:14:38Z
dc.date.issued1995-11-01
dc.date.submitted2008-10-09
dc.identifier.citationNat Med. 1995 Nov;1(11):1189-94.
dc.identifier.issn1078-8956 (Print)
dc.identifier.pmid7584993
dc.identifier.urihttp://hdl.handle.net/20.500.14038/33906
dc.description.abstractClinical trials are under way using fetal cells to repair damaged neuronal circuitry. However, little is known about how transplanted immature neurons can grow anatomically correct connections in the adult central nervous system (CNS). We transplanted embryonic porcine neural cells in vivo into adult rat brains with neuronal and axonal loss typical of Parkinson's or Huntington's disease. Using complementary species-specific cellular markers, we found donor axons and CD44+ astroglial fibres in host white matter tracts up to 8 mm from CNS transplant sites, although only donor axons were capable of reaching correct gray matter target regions. This work demonstrates that adult host brain can orient growth of transplanted neurons and that there are differences in transplant donor glial and axonal growth patterns in cellular repair of the mature CNS.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7584993&dopt=Abstract">Link to article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1038/nm1195-1189
dc.subjectAnimals; Axons; Basal Ganglia Diseases; Biological Markers; Brain; Cells, Cultured; Disease Models, Animal; Huntington Disease; Immunohistochemistry; Male; Neuroglia; Neurons; Parkinson Disease; Rats; Rats, Sprague-Dawley; Swine; *Transplantation, Heterologous
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleTransplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial and axonal fibres
dc.typeJournal Article
dc.source.journaltitleNature medicine
dc.source.volume1
dc.source.issue11
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/561
dc.identifier.contextkey646746
html.description.abstract<p>Clinical trials are under way using fetal cells to repair damaged neuronal circuitry. However, little is known about how transplanted immature neurons can grow anatomically correct connections in the adult central nervous system (CNS). We transplanted embryonic porcine neural cells in vivo into adult rat brains with neuronal and axonal loss typical of Parkinson's or Huntington's disease. Using complementary species-specific cellular markers, we found donor axons and CD44+ astroglial fibres in host white matter tracts up to 8 mm from CNS transplant sites, although only donor axons were capable of reaching correct gray matter target regions. This work demonstrates that adult host brain can orient growth of transplanted neurons and that there are differences in transplant donor glial and axonal growth patterns in cellular repair of the mature CNS.</p>
dc.identifier.submissionpathgsbs_sp/561
dc.contributor.departmentProgram in Neuroscience
dc.contributor.departmentGraduate School of Biomedical Sciences
dc.source.pages1189-94


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