Cutting edge: MHC class II-restricted killing in vivo during viral infection
| dc.contributor.author | Jellison, Evan Robert | |
| dc.contributor.author | Kim, Sung-Kwon | |
| dc.contributor.author | Welsh, Raymond M. | |
| dc.date | 2022-08-11T08:08:59.000 | |
| dc.date.accessioned | 2022-08-23T16:14:44Z | |
| dc.date.available | 2022-08-23T16:14:44Z | |
| dc.date.issued | 2005-01-07 | |
| dc.date.submitted | 2008-10-09 | |
| dc.identifier.citation | <p>J Immunol. 2005 Jan 15;174(2):614-8.</p> | |
| dc.identifier.issn | 0022-1767 (Print) | |
| dc.identifier.doi | 10.4049/jimmunol.174.2.614 | |
| dc.identifier.pmid | 15634878 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14038/33932 | |
| dc.description.abstract | Class II-restricted CD4 T cell-mediated killing of target cells has previously been documented in vitro but not in vivo. In this study, we demonstrate CD4-dependent MHC class II-restricted killing in lymphocytic choriomeningitis virus-infected mice in vivo using an in vivo cytotoxicity assay that features class II-expressing B cells as targets. | |
| dc.language.iso | en_US | |
| dc.relation | <p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15634878&dopt=Abstract">Link to article in PubMed</a></p> | |
| dc.relation.url | https://doi.org/10.4049/jimmunol.174.2.614 | |
| dc.subject | Adoptive Transfer; Amino Acid Sequence; Animals; Antigen Presentation; Antigens, CD95; Antigens, Viral; CD4-Positive T-Lymphocytes; *Cytotoxicity, Immunologic; Epitopes, T-Lymphocyte; Fas Ligand Protein; Glycoproteins; Histocompatibility Antigens Class II; Influenza A virus; Lymphocyte Depletion; Lymphocytic Choriomeningitis; Lymphocytic choriomeningitis virus; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Sequence Data; Receptors, Antigen, T-Cell, alpha-beta; Spleen; Viral Proteins | |
| dc.subject | Life Sciences | |
| dc.subject | Medicine and Health Sciences | |
| dc.title | Cutting edge: MHC class II-restricted killing in vivo during viral infection | |
| dc.type | Journal Article | |
| dc.source.journaltitle | Journal of immunology (Baltimore, Md. : 1950) | |
| dc.source.volume | 174 | |
| dc.source.issue | 2 | |
| dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/gsbs_sp/585 | |
| dc.identifier.contextkey | 646770 | |
| html.description.abstract | <p>Class II-restricted CD4 T cell-mediated killing of target cells has previously been documented in vitro but not in vivo. In this study, we demonstrate CD4-dependent MHC class II-restricted killing in lymphocytic choriomeningitis virus-infected mice in vivo using an in vivo cytotoxicity assay that features class II-expressing B cells as targets.</p> | |
| dc.identifier.submissionpath | gsbs_sp/585 | |
| dc.contributor.department | Department of Pathology | |
| dc.contributor.department | Program in Immunology and Virology | |
| dc.contributor.department | Graduate School of Biomedical Sciences | |
| dc.source.pages | 614-8 |
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