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    Diverse odor-conditioned memories require uniquely timed dorsal paired medial neuron output

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    Authors
    Keene, Alex Carl
    Stratmann, Markus
    Keller, Andreas
    Perrat, Paola N.
    Vosshall, Leslie B.
    Waddell, Scott
    Student Authors
    Alex Keene
    Paola Perrat
    Academic Program
    Neuroscience
    UMass Chan Affiliations
    Graduate School of Biomedical Sciences, Neuroscience Program
    Waddell Lab
    Neurobiology
    Document Type
    Journal Article
    Publication Date
    2004-10-28
    Keywords
    Analysis of Variance; Animals; Animals, Genetically Modified; Avoidance Learning; Behavior, Animal; Benzaldehydes; Brain; Conditioning (Psychology); Drosophila; Drosophila Proteins; Fushi Tarazu Transcription Factors; Histocytochemistry; Maze Learning; Memory; Microscopy, Confocal; Mushroom Bodies; Mutagenesis; Neurons; Neuropeptides; *Odors; Olfactory Pathways; Recombinant Fusion Proteins; Temperature; Time Factors; Trans-Activators
    Neuroscience and Neurobiology
    
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    Link to Full Text
    http://dx.doi.org/10.1016/j.neuron.2004.10.006
    Abstract
    Amnesiac mutant flies have an olfactory memory defect. The amn gene encodes a homolog of vertebrate pituitary adenylate cyclase-activating peptide (PACAP), and it is strongly expressed in dorsal paired medial (DPM) neurons. DPM neurons ramify throughout the mushroom bodies in the adult fly brain, and they are required for stable memory. Here, we show that DPM neuron output is only required during the consolidation phase for middle-term odor memory and is dispensable during acquisition and recall. However, we found that DPM neuron output is required during acquisition of a benzaldehyde odor memory. We show that flies sense benzaldehyde by the classical olfactory and a noncanonical route. These results suggest that DPM neurons are required to consolidate memory and are differently involved in memory of a volatile that requires multisensory integration.
    Source
    Neuron. 2004 Oct 28;44(3):521-33. Link to article on publisher's site
    DOI
    10.1016/j.neuron.2004.10.006
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/33943
    PubMed ID
    15504331
    Related Resources
    Link to article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.neuron.2004.10.006
    Scopus Count
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    Morningside GSBS Scholarly Publications
    Neurobiology Student Publications
    Neurobiology Faculty Publications

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