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dc.contributor.authorKeene, Alex Carl
dc.contributor.authorStratmann, Markus
dc.contributor.authorKeller, Andreas
dc.contributor.authorPerrat, Paola N.
dc.contributor.authorVosshall, Leslie B.
dc.contributor.authorWaddell, Scott
dc.date2022-08-11T08:08:59.000
dc.date.accessioned2022-08-23T16:14:47Z
dc.date.available2022-08-23T16:14:47Z
dc.date.issued2004-10-28
dc.date.submitted2008-10-09
dc.identifier.citationNeuron. 2004 Oct 28;44(3):521-33. <a href="http://dx.doi.org/10.1016/j.neuron.2004.10.006 ">Link to article on publisher's site</a>
dc.identifier.issn0896-6273 (Print)
dc.identifier.doi10.1016/j.neuron.2004.10.006
dc.identifier.pmid15504331
dc.identifier.urihttp://hdl.handle.net/20.500.14038/33943
dc.description.abstractAmnesiac mutant flies have an olfactory memory defect. The amn gene encodes a homolog of vertebrate pituitary adenylate cyclase-activating peptide (PACAP), and it is strongly expressed in dorsal paired medial (DPM) neurons. DPM neurons ramify throughout the mushroom bodies in the adult fly brain, and they are required for stable memory. Here, we show that DPM neuron output is only required during the consolidation phase for middle-term odor memory and is dispensable during acquisition and recall. However, we found that DPM neuron output is required during acquisition of a benzaldehyde odor memory. We show that flies sense benzaldehyde by the classical olfactory and a noncanonical route. These results suggest that DPM neurons are required to consolidate memory and are differently involved in memory of a volatile that requires multisensory integration.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15504331&dopt=Abstract">Link to article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/j.neuron.2004.10.006
dc.subjectAnalysis of Variance; Animals; Animals, Genetically Modified; Avoidance Learning; Behavior, Animal; Benzaldehydes; Brain; Conditioning (Psychology); Drosophila; Drosophila Proteins; Fushi Tarazu Transcription Factors; Histocytochemistry; Maze Learning; Memory; Microscopy, Confocal; Mushroom Bodies; Mutagenesis; Neurons; Neuropeptides; *Odors; Olfactory Pathways; Recombinant Fusion Proteins; Temperature; Time Factors; Trans-Activators
dc.subjectNeuroscience and Neurobiology
dc.titleDiverse odor-conditioned memories require uniquely timed dorsal paired medial neuron output
dc.typeJournal Article
dc.source.journaltitleNeuron
dc.source.volume44
dc.source.issue3
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/596
dc.identifier.contextkey646781
html.description.abstract<p>Amnesiac mutant flies have an olfactory memory defect. The amn gene encodes a homolog of vertebrate pituitary adenylate cyclase-activating peptide (PACAP), and it is strongly expressed in dorsal paired medial (DPM) neurons. DPM neurons ramify throughout the mushroom bodies in the adult fly brain, and they are required for stable memory. Here, we show that DPM neuron output is only required during the consolidation phase for middle-term odor memory and is dispensable during acquisition and recall. However, we found that DPM neuron output is required during acquisition of a benzaldehyde odor memory. We show that flies sense benzaldehyde by the classical olfactory and a noncanonical route. These results suggest that DPM neurons are required to consolidate memory and are differently involved in memory of a volatile that requires multisensory integration.</p>
dc.identifier.submissionpathgsbs_sp/596
dc.contributor.departmentGraduate School of Biomedical Sciences, Neuroscience Program
dc.contributor.departmentWaddell Lab
dc.contributor.departmentNeurobiology
dc.source.pages521-33
dc.contributor.studentAlex Keene
dc.contributor.studentPaola Perrat
dc.description.thesisprogramNeuroscience


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