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dc.contributor.authorKeene, Alex Carl
dc.contributor.authorWaddell, Scott
dc.date2022-08-11T08:08:59.000
dc.date.accessioned2022-08-23T16:14:47Z
dc.date.available2022-08-23T16:14:47Z
dc.date.issued2007-05-01
dc.date.submitted2008-10-09
dc.identifier.citationNat Rev Neurosci. 2007 May;8(5):341-54. <a href="http://dx.doi.org/10.1038/nrn2098 ">Link to article on publisher's site</a>
dc.identifier.issn1471-003X (Print)
dc.identifier.doi10.1038/nrn2098
dc.identifier.pmid17453015
dc.identifier.urihttp://hdl.handle.net/20.500.14038/33944
dc.description.abstractA central goal of neuroscience is to understand how neural circuits encode memory and guide behaviour. Studying simple, genetically tractable organisms, such as Drosophila melanogaster, can illuminate principles of neural circuit organization and function. Early genetic dissection of D. melanogaster olfactory memory focused on individual genes and molecules. These molecular tags subsequently revealed key neural circuits for memory. Recent advances in genetic technology have allowed us to manipulate and observe activity in these circuits, and even individual neurons, in live animals. The studies have transformed D. melanogaster from a useful organism for gene discovery to an ideal model to understand neural circuit function in memory.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17453015&dopt=Abstract">Link to article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1038/nrn2098
dc.subjectAnimals; Drosophila; Genes, Insect; Memory; Nerve Net; Olfactory Pathways
dc.subjectNeuroscience and Neurobiology
dc.titleDrosophila olfactory memory: single genes to complex neural circuits
dc.typeJournal Article
dc.source.journaltitleNature reviews. Neuroscience
dc.source.volume8
dc.source.issue5
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/598
dc.identifier.contextkey646783
html.description.abstract<p>A central goal of neuroscience is to understand how neural circuits encode memory and guide behaviour. Studying simple, genetically tractable organisms, such as Drosophila melanogaster, can illuminate principles of neural circuit organization and function. Early genetic dissection of D. melanogaster olfactory memory focused on individual genes and molecules. These molecular tags subsequently revealed key neural circuits for memory. Recent advances in genetic technology have allowed us to manipulate and observe activity in these circuits, and even individual neurons, in live animals. The studies have transformed D. melanogaster from a useful organism for gene discovery to an ideal model to understand neural circuit function in memory.</p>
dc.identifier.submissionpathgsbs_sp/598
dc.contributor.departmentGraduate School of Biomedical Sciences, Neuroscience Program
dc.contributor.departmentWaddell Lab
dc.contributor.departmentNeurobiology
dc.source.pages341-54
dc.contributor.studentAlex Keene
dc.description.thesisprogramNeuroscience


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