Private specificities of CD8 T cell responses control patterns of heterologous immunity
Wang, Xiaoting Z.
Chen, Hong D.
Selin, Liisa K.
Welsh, Raymond M.
UMass Chan AffiliationsDepartment of Pathology
Program in Immunology and Virology
Graduate School of Biomedical Sciences
Document TypeJournal Article
KeywordsAdoptive Transfer; Animals; CD8-Positive T-Lymphocytes; Cross Reactions; Epitopes, T-Lymphocyte; *Immunologic Memory; Lymphocytic choriomeningitis virus; Male; Mice; Mice, Inbred C57BL; Receptors, Interleukin-7; Spleen; Vaccinia virus
Medicine and Health Sciences
MetadataShow full item record
AbstractCD8 T cell cross-reactivity between viruses can play roles in protective heterologous immunity and damaging immunopathology. This cross-reactivity is sometimes predictable, such as between lymphocytic choriomeningitis virus (LCMV) and Pichinde virus, where cross-reactive epitopes share six out of eight amino acids. Here, however, we demonstrate more subtle and less predictable cross-reactivity between LCMV and the unrelated vaccinia virus (VV). Epitope-specific T cell receptor usage differed between individual LCMV-infected C57BL/6 mice, even though the mice had similar epitope-specific T cell hierarchies. LCMV-immune mice challenged with VV showed variations, albeit in a distinct hierarchy, in proliferative expansions of and down-regulation of IL-7Ralpha by T cells specific to different LCMV epitopes. T cell responses to a VV-encoded epitope that is cross-reactive with LCMV fluctuated greatly in VV-infected LCMV-immune mice. Adoptive transfers of splenocytes from individual LCMV-immune donors resulted in nearly identical VV-induced responses in each of several recipients, but responses differed depending on the donor. This indicates that the specificities of T cell responses that are not shared between individuals may influence cross-reactivity with other antigens and play roles in heterologous immunity upon encounter with another pathogen. This variability in cross-reactive T cell expansion that is unique to the individual may underlie variation in the pathogenesis of infectious diseases.
SourceJ Exp Med. 2005 Feb 21;201(4):523-33. Epub 2005 Feb 14. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/33951
Related ResourcesLink to article in PubMed