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    The bone-related Zn finger transcription factor Osterix promotes proliferation of mesenchymal cells

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    Authors
    Kim, Yeon-Ju
    Kim, Hyun-Nam
    Park, Eui-Kyun
    Lee, Byung-Heon
    Ryoo, Hyun-Mo
    Kim, Shin-Yoon
    Kim, In-San
    Stein, Janet L.
    Lian, Jane B.
    Stein, Gary S.
    Van Wijnen, Andre J.
    Choi, Je-Yong
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    UMass Chan Affiliations
    Department of Cell Biology
    Graduate School of Biomedical Sciences
    Document Type
    Journal Article
    Publication Date
    2005-11-30
    Keywords
    Animals; Antigens, Differentiation; Cell Differentiation; *Cell Proliferation; Core Binding Factor Alpha 1 Subunit; Gene Expression Regulation; Mesoderm; Mice; NIH 3T3 Cells; Osteoblasts; Osteogenesis; Signal Transduction; Transcription Factors; Transfection
    Life Sciences
    Medicine and Health Sciences
    
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    Link to Full Text
    http://dx.doi.org/10.1016/j.gene.2005.08.021
    Abstract
    Osterix is a bone-related transcription factor that functions genetically downstream of Runx2, which controls both growth and differentiation in osteoblasts. Here we assessed the biological function of Osterix in mesenchymal cells that are not normally committed to the osteogenic lineage. Stably transfected NIH3T3 fibroblasts that express exogenous Osterix were examined for their ability to convert into osteoblastic cells by analyzing gene expression profiles of bone phenotype related markers, as well as by measuring bone nodule formation and cell proliferation. Forced expression of Osterix stimulates osteopontin gene expression but not the expression or activity of other bone-related markers, including collagen type I, alkaline phosphatase, osteocalcin, or osteonectin. Moreover, cells stably expressing Osterix do not induce bone nodule formation. Strikingly, both polyclonal and monoclonal cells expressing Osterix exhibit enhanced proliferation. Collectively, these results indicate that Osterix is insufficient to establish osteogenic lineage commitment, perhaps due to the ability of Osterix to promote cell growth. We propose that regulatory pathways operating upstream of or in parallel with Osterix are required for osteogenic conversion of uncommitted mesenchymal cells.
    Source
    Gene. 2006 Jan 17;366(1):145-51. Epub 2005 Nov 28. Link to article on publisher's site
    DOI
    10.1016/j.gene.2005.08.021
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/33952
    PubMed ID
    16314050
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    Link to article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.gene.2005.08.021
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