• Login
    View Item 
    •   Home
    • UMass Chan Student Research and Publications
    • Morningside Graduate School of Biomedical Sciences
    • Morningside Graduate School of Biomedical Sciences Scholarly Publications
    • View Item
    •   Home
    • UMass Chan Student Research and Publications
    • Morningside Graduate School of Biomedical Sciences
    • Morningside Graduate School of Biomedical Sciences Scholarly Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of eScholarship@UMassChanCommunitiesPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywordsThis CollectionPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywords

    My Account

    LoginRegister

    Help

    AboutSubmission GuidelinesData Deposit PolicySearchingAccessibilityTerms of UseWebsite Migration FAQ

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Sonic hedgehog has a dual effect on the growth of retinal ganglion axons depending on its concentration

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Kolpak, Adrianne L.
    Zhang, Jinhua
    Bao, Zheng-Zheng
    UMass Chan Affiliations
    Department of Medicine, Division of Endocrinology and Metabolism
    Department of Cell Biology
    Graduate School of Biomedical Sciences
    Document Type
    Journal Article
    Publication Date
    2005-04-01
    Keywords
    Age Factors; Animals; Axons; Cells, Cultured; Chick Embryo; Coculture Techniques; Dose-Response Relationship, Drug; Drug Interactions; Fluorescent Antibody Technique; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; Growth Cones; Hedgehog Proteins; In Situ Hybridization; Neural Inhibition; Optic Disk; Organ Culture Techniques; RNA, Messenger; Recombinant Proteins; Retina; Retinal Ganglion Cells; Time Factors; Trans-Activators; Veratrum Alkaloids
    Life Sciences
    Medicine and Health Sciences
    
    Metadata
    Show full item record
    Link to Full Text
    http://dx.doi.org/10.1523/JNEUROSCI.4938-04.2005
    Abstract
    The stereotypical projection of retinal ganglion cell (RGC) axons to the optic disc has served as a good model system for studying axon guidance. By both in vitro and in vivo experiments, we show that a secreted molecule, Sonic hedgehog (Shh), may play a critical role in the process. It is expressed in a dynamic pattern in the ganglion cell layer with a relatively higher expression in the center of the retina. Through gel culture and stripe assays, we show that Shh has a dual effect on RGC axonal growth, acting as a positive factor at low concentrations and a negative factor at high concentrations. Results from time-lapse video microscopic and stripe assay experiments further suggest that the effects of Shh on axons are not likely attributable to indirect transcriptional regulation by Shh. Overexpression of Shh protein or inhibition of Shh function inside the retina resulted in a complete loss of centrally directed projection of RGC axons, suggesting that precise regulation of Shh level inside the retina is critical for the projection of RGC axons to the optic disc.
    Source
    J Neurosci. 2005 Mar 30;25(13):3432-41. Link to article on publisher's site
    DOI
    10.1523/JNEUROSCI.4938-04.2005
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/33966
    PubMed ID
    15800198
    Related Resources
    Link to article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1523/JNEUROSCI.4938-04.2005
    Scopus Count
    Collections
    Morningside Graduate School of Biomedical Sciences Scholarly Publications

    entitlement

    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Lamar Soutter Library, UMass Chan Medical School | 55 Lake Avenue North | Worcester, MA 01655 USA
    Quick Guide | escholarship@umassmed.edu
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.