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    A role for nuclear PTEN in neuronal differentiation

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    Authors
    Lachyankar, Mahesh B.
    Sultana, Nazneen
    Schonhoff, Christopher M.
    Mitra, Prasenjit
    Poluha, Wojciech
    Lambert, Stephen
    Quesenberry, Peter J.
    Litofsky, N. Scott
    Recht, Lawrence D.
    Nabi, Roya
    Miller, Susan J.
    Ohta, Shinji
    Neel, Benjamin G.
    Ross, Alonzo H.
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    UMass Chan Affiliations
    Department of Biochemistry and Molecular Pharmacology
    Department of Neurology
    Cancer Center
    Department of Cell Biology
    Department of Pharmacology
    Graduate School of Biomedical Sciences
    Document Type
    Journal Article
    Publication Date
    2000-02-09
    Keywords
    Animals; Astrocytes; Brain; Cell Differentiation; Cells, Cultured; Central Nervous System; Embryo, Mammalian; Genes, Tumor Suppressor; Glioma; Hippocampus; Humans; Mice; Neurons; Olfactory Bulb; Oligodendroglia; PC12 Cells; PTEN Phosphohydrolase; Phosphoric Monoester Hydrolases; Rats; Recombinant Fusion Proteins; Stem Cells; *Tumor Suppressor Proteins
    Life Sciences
    Medicine and Health Sciences
    
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    Link to Full Text
    https://doi.org/10.1523/JNEUROSCI.20-04-01404.2000
    Abstract
    Mutations of phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a protein and lipid phosphatase, have been associated with gliomas, macrocephaly, and mental deficiencies. We have assessed PTEN's role in the nervous system and find that PTEN is expressed in mouse brain late in development, starting at approximately postnatal day 0. In adult brain, PTEN is preferentially expressed in neurons and is especially evident in Purkinje neurons, olfactory mitral neurons, and large pyramidal neurons. To analyze the function of PTEN in neuronal differentiation, we used two well established model systems-pheochromocytoma cells and cultured CNS stem cells. PTEN is expressed during neurotrophin-induced differentiation and is detected in both the nucleus and cytoplasm. Suppression of PTEN levels with antisense oligonucleotides does not block initiation of neuronal differentiation. Instead, PTEN antisense leads to death of the resulting, immature neurons, probably during neurite extension. In contrast, PTEN is not required for astrocytic differentiation. These observations indicate that PTEN acts at multiple sites in the cell, regulating the transition of differentiating neuroblasts to postmitotic neurons.
    Source

    J Neurosci. 2000 Feb 15;20(4):1404-13.

    DOI
    10.1523/JNEUROSCI.20-04-01404.2000
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/33982
    PubMed ID
    10662831
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    Link to article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1523/JNEUROSCI.20-04-01404.2000
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