Construction of centrosomes and spindle poles by molecular motor-driven assembly of protein particles
Document Type
Journal ArticlePublication Date
2001-02-24Keywords
Animals; Antigens; Autoantigens; Biological Transport; CHO Cells; *Cell Cycle Proteins; Centrosome; Cricetinae; Dynein ATPase; Microtubules; Mitotic Spindle Apparatus; Models, Molecular; Molecular Motor Proteins; Nuclear ProteinsLife Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Centrosomes and other microtubule organizing centers are the largest non-membranous organelles in most cells. This morphologically diverse class of organelles shares a common ability to nucleate and organize microtubules in interphase and participates in the formation of mitotic spindles during cell division. This review summarizes recent evidence suggesting that assembly of centrosomes and mitotic spindle poles require transport of large protein particles along microtubules by the molecular motor cytoplasmic dynein.Source
Traffic. 2000 Dec;1(12):927-34.
DOI
10.1111/j.1600-0854.2000.11202.xPermanent Link to this Item
http://hdl.handle.net/20.500.14038/34011PubMed ID
11208082Related Resources
ae974a485f413a2113503eed53cd6c53
10.1111/j.1600-0854.2000.11202.x