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dc.contributor.authorZimmerman, Wendy Cherie
dc.contributor.authorSparks, Cynthia A.
dc.contributor.authorDoxsey, Stephen J.
dc.date2022-08-11T08:09:00.000
dc.date.accessioned2022-08-23T16:15:07Z
dc.date.available2022-08-23T16:15:07Z
dc.date.issued1999-02-27
dc.date.submitted2008-10-16
dc.identifier.citation<p>Curr Opin Cell Biol. 1999 Feb;11(1):122-8.</p>
dc.identifier.issn0955-0674 (Print)
dc.identifier.doi10.1016/S0955-0674(99)80015-5
dc.identifier.pmid10047524
dc.identifier.urihttp://hdl.handle.net/20.500.14038/34013
dc.description.abstractRecent genetic and biochemical studies have provided new insights into the molecular basis of centrosome-mediated microtubule nucleation. In addition, molecules and mechanisms involved in microtubule severing and stabilization at the centrosome, assembly of proteins onto centrosomes and regulation of centrosome duplication and separation are being defined. Characterization of centrosome function, together with studies implicating centrosomes in tumorigenesis and demonstrating that centrosomes are highly organized, are beginning to bring into focus an organelle once viewed as an 'amorphous cloud'.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=10047524&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.1016/S0955-0674(99)80015-5
dc.subjectAnimals; Cell Nucleus; Centrosome; Microtubules; Mitosis; Models, Biological; Neoplasms; Tubulin
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleAmorphous no longer: the centrosome comes into focus
dc.typeJournal Article
dc.source.journaltitleCurrent opinion in cell biology
dc.source.volume11
dc.source.issue1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/665
dc.identifier.contextkey652003
html.description.abstract<p>Recent genetic and biochemical studies have provided new insights into the molecular basis of centrosome-mediated microtubule nucleation. In addition, molecules and mechanisms involved in microtubule severing and stabilization at the centrosome, assembly of proteins onto centrosomes and regulation of centrosome duplication and separation are being defined. Characterization of centrosome function, together with studies implicating centrosomes in tumorigenesis and demonstrating that centrosomes are highly organized, are beginning to bring into focus an organelle once viewed as an 'amorphous cloud'.</p>
dc.identifier.submissionpathgsbs_sp/665
dc.contributor.departmentProgram in Molecular Medicine
dc.contributor.departmentGraduate School of Biomedical Sciences
dc.source.pages122-8


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