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Activation of the bone-related Runx2/Cbfa1 promoter in mesenchymal condensations and developing chondrocytes of the axial skeleton

dc.contributor.authorLengner, Christopher J.
dc.contributor.authorDrissi, Hicham
dc.contributor.authorChoi, Je-Yong
dc.contributor.authorVan Wijnen, Andre J.
dc.contributor.authorStein, Janet L.
dc.contributor.authorStein, Gary S.
dc.contributor.authorLian, Jane B.
dc.date2022-08-11T08:09:00.000
dc.date.accessioned2022-08-23T16:15:09Z
dc.date.available2022-08-23T16:15:09Z
dc.date.issued2002-08-15
dc.date.submitted2008-10-22
dc.identifier.citation<p>Mech Dev. 2002 Jun;114(1-2):167-70.</p>
dc.identifier.issn0925-4773 (Print)
dc.identifier.doi10.1016/S0925-4773(02)00050-3
dc.identifier.pmid12175505
dc.identifier.urihttp://hdl.handle.net/20.500.14038/34020
dc.description.abstractThe Runx2/Cbfa1 transcription factor regulates a program of gene expression necessary for skeletal development. To understand signals mediating skeletal formation, we examined the in vivo spatio-temporal activity of the Runx2 P1 promoter which controls expression of the bone-related Type II isoform. Transgenic mice carrying 3 kb of Runx2 promoter fused to the lacZ gene exhibit localized promoter activity in early mesenchymal condensations shortly after the embryonic turning event. Expression in developing mesenchyme continues throughout chondrogenesis and is restricted to the axial skeleton. Our data support a function for Runx2 in establishment of the prechondrocytic skeletal primordium.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12175505&dopt=Abstract">Link to article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.1016/S0925-4773(02)00050-3
dc.subjectAnimals; Bone and Bones; Chondrocytes; Core Binding Factor Alpha 1 Subunit; Mesoderm; Mice; Mice, Transgenic; Models, Genetic; *Neoplasm Proteins; *Promoter Regions (Genetics); Protein Isoforms; Signal Transduction; Time Factors; Transcription Factors
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleActivation of the bone-related Runx2/Cbfa1 promoter in mesenchymal condensations and developing chondrocytes of the axial skeleton
dc.typeJournal Article
dc.source.journaltitleMechanisms of development
dc.source.volume114
dc.source.issue1-2
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/671
dc.identifier.contextkey654563
html.description.abstract<p>The Runx2/Cbfa1 transcription factor regulates a program of gene expression necessary for skeletal development. To understand signals mediating skeletal formation, we examined the in vivo spatio-temporal activity of the Runx2 P1 promoter which controls expression of the bone-related Type II isoform. Transgenic mice carrying 3 kb of Runx2 promoter fused to the lacZ gene exhibit localized promoter activity in early mesenchymal condensations shortly after the embryonic turning event. Expression in developing mesenchyme continues throughout chondrogenesis and is restricted to the axial skeleton. Our data support a function for Runx2 in establishment of the prechondrocytic skeletal primordium.</p>
dc.identifier.submissionpathgsbs_sp/671
dc.contributor.departmentDepartment of Cell Biology
dc.contributor.departmentGraduate School of Biomedical Sciences
dc.source.pages167-70


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