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dc.contributor.authorYu, Dinghui
dc.contributor.authorKeene, Alex Carl
dc.contributor.authorSrivatsan, Anjana
dc.contributor.authorWaddell, Scott
dc.contributor.authorDavis, Ronald L.
dc.date2022-08-11T08:09:00.000
dc.date.accessioned2022-08-23T16:15:18Z
dc.date.available2022-08-23T16:15:18Z
dc.date.issued2005-12-02
dc.date.submitted2008-10-27
dc.identifier.citationCell. 2005 Dec 2;123(5):945-57. <a href="http://dx.doi.org/10.1016/j.cell.2005.09.037">Link to article on publisher's site</a>
dc.identifier.issn0092-8674 (Print)
dc.identifier.doi10.1016/j.cell.2005.09.037
dc.identifier.pmid16325586
dc.identifier.urihttp://hdl.handle.net/20.500.14038/34055
dc.description.abstractFormation of normal olfactory memory requires the expression of the wild-type amnesiac gene in the dorsal paired medial (DPM) neurons. Imaging the activity in the processes of DPM neurons revealed that the neurons respond when the fly is stimulated with electric shock or with any odor that was tested. Pairing odor and electric-shock stimulation increases odor-evoked calcium signals and synaptic release from DPM neurons. These memory traces form in only one of the two branches of the DPM neuron process. Moreover, trace formation requires the expression of the wild-type amnesiac gene in the DPM neurons. The cellular memory traces first appear at 30 min after conditioning and persist for at least 1 hr, a time window during which DPM neuron synaptic transmission is required for normal memory. DPM neurons are therefore "odor generalists" and form a delayed, branch-specific, and amnesiac-dependent memory trace that may guide behavior after acquisition.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=16325586&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/j.cell.2005.09.037
dc.subjectAnimals; Calcium; Conditioning, Classical; Drosophila Proteins; *Drosophila melanogaster; Electric Stimulation; Memory; Neurons; Neuropeptides; Odors; Smell; Synaptic Transmission; Time Factors; Transgenes
dc.subjectNeuroscience and Neurobiology
dc.titleDrosophila DPM neurons form a delayed and branch-specific memory trace after olfactory classical conditioning
dc.typeJournal Article
dc.source.journaltitleCell
dc.source.volume123
dc.source.issue5
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/703
dc.identifier.contextkey656745
html.description.abstract<p>Formation of normal olfactory memory requires the expression of the wild-type amnesiac gene in the dorsal paired medial (DPM) neurons. Imaging the activity in the processes of DPM neurons revealed that the neurons respond when the fly is stimulated with electric shock or with any odor that was tested. Pairing odor and electric-shock stimulation increases odor-evoked calcium signals and synaptic release from DPM neurons. These memory traces form in only one of the two branches of the DPM neuron process. Moreover, trace formation requires the expression of the wild-type amnesiac gene in the DPM neurons. The cellular memory traces first appear at 30 min after conditioning and persist for at least 1 hr, a time window during which DPM neuron synaptic transmission is required for normal memory. DPM neurons are therefore "odor generalists" and form a delayed, branch-specific, and amnesiac-dependent memory trace that may guide behavior after acquisition.</p>
dc.identifier.submissionpathgsbs_sp/703
dc.contributor.departmentGraduate School of Biomedical Sciences, Neuroscience Program
dc.contributor.departmentWaddell Lab
dc.contributor.departmentNeurobiology
dc.source.pages945-57
dc.contributor.studentAlex Keene
dc.description.thesisprogramNeuroscience


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