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    The dynamic organization of gene-regulatory machinery in nuclear microenvironments

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    Authors
    Zaidi, Sayyed K.
    Young, Daniel W.
    Choi, Je-Yong
    Pratap, Jitesh
    Javed, Amjad
    Montecino, Martin A.
    Stein, Janet L.
    Van Wijnen, Andre J.
    Lian, Jane B.
    Stein, Gary S.
    UMass Chan Affiliations
    Graduate School of Biomedical Sciences
    Department of Cell Biology
    Document Type
    Journal Article
    Publication Date
    2005-02-04
    Keywords
    Animals; Cell Nucleus; Core Binding Factor Alpha 2 Subunit; DNA-Binding Proteins; Gene Expression Regulation; Humans; Nuclear Matrix; Protein Transport; Proto-Oncogene Proteins; Transcription Factors; Transcription, Genetic
    Life Sciences
    Medicine and Health Sciences
    
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    Link to Full Text
    http://dx.doi.org/10.1038/sj.embor.7400337
    Abstract
    Nuclear components are functionally linked with the dynamic temporal and spatial compartmentalization, sorting and integration of regulatory information to facilitate its selective use. For example, the subnuclear targeting of transcription factors to punctate sites in the interphase nucleus mechanistically couples chromatin remodelling and the execution of signalling cascades that mediate gene expression with the combinatorial assembly of the regulatory machinery for biological control. In addition, a mitotic cycle of selective partitioning and sequential restoration of the transcriptional machinery provides a basis for the reassembly of regulatory complexes to render progeny cells competent for phenotypic gene expression. When this intranuclear targeting and localization of regulatory proteins is compromised, diseases, such as cancer, can occur. A detailed understanding of this process will provide further options for diagnosis and treatment.
    Source
    EMBO Rep. 2005 Feb;6(2):128-33. Link to article on publisher's site
    DOI
    10.1038/sj.embor.7400337
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/34065
    PubMed ID
    15689940
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1038/sj.embor.7400337
    Scopus Count
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    Morningside GSBS Scholarly Publications

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