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dc.contributor.authorZaidi, Sayyed K.
dc.contributor.authorYoung, Daniel W.
dc.contributor.authorChoi, Je-Yong
dc.contributor.authorPratap, Jitesh
dc.contributor.authorJaved, Amjad
dc.contributor.authorMontecino, Martin A.
dc.contributor.authorStein, Janet L.
dc.contributor.authorVan Wijnen, Andre J.
dc.contributor.authorLian, Jane B.
dc.contributor.authorStein, Gary S.
dc.date2022-08-11T08:09:00.000
dc.date.accessioned2022-08-23T16:15:21Z
dc.date.available2022-08-23T16:15:21Z
dc.date.issued2005-02-04
dc.date.submitted2008-10-27
dc.identifier.citationEMBO Rep. 2005 Feb;6(2):128-33. <a href="http://dx.doi.org/10.1038/sj.embor.7400337">Link to article on publisher's site</a>
dc.identifier.issn1469-221X (Print)
dc.identifier.doi10.1038/sj.embor.7400337
dc.identifier.pmid15689940
dc.identifier.urihttp://hdl.handle.net/20.500.14038/34065
dc.description.abstractNuclear components are functionally linked with the dynamic temporal and spatial compartmentalization, sorting and integration of regulatory information to facilitate its selective use. For example, the subnuclear targeting of transcription factors to punctate sites in the interphase nucleus mechanistically couples chromatin remodelling and the execution of signalling cascades that mediate gene expression with the combinatorial assembly of the regulatory machinery for biological control. In addition, a mitotic cycle of selective partitioning and sequential restoration of the transcriptional machinery provides a basis for the reassembly of regulatory complexes to render progeny cells competent for phenotypic gene expression. When this intranuclear targeting and localization of regulatory proteins is compromised, diseases, such as cancer, can occur. A detailed understanding of this process will provide further options for diagnosis and treatment.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=15689940&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1038/sj.embor.7400337
dc.subjectAnimals; Cell Nucleus; Core Binding Factor Alpha 2 Subunit; DNA-Binding Proteins; Gene Expression Regulation; Humans; Nuclear Matrix; Protein Transport; Proto-Oncogene Proteins; Transcription Factors; Transcription, Genetic
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleThe dynamic organization of gene-regulatory machinery in nuclear microenvironments
dc.typeJournal Article
dc.source.journaltitleEMBO reports
dc.source.volume6
dc.source.issue2
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/712
dc.identifier.contextkey656754
html.description.abstract<p>Nuclear components are functionally linked with the dynamic temporal and spatial compartmentalization, sorting and integration of regulatory information to facilitate its selective use. For example, the subnuclear targeting of transcription factors to punctate sites in the interphase nucleus mechanistically couples chromatin remodelling and the execution of signalling cascades that mediate gene expression with the combinatorial assembly of the regulatory machinery for biological control. In addition, a mitotic cycle of selective partitioning and sequential restoration of the transcriptional machinery provides a basis for the reassembly of regulatory complexes to render progeny cells competent for phenotypic gene expression. When this intranuclear targeting and localization of regulatory proteins is compromised, diseases, such as cancer, can occur. A detailed understanding of this process will provide further options for diagnosis and treatment.</p>
dc.identifier.submissionpathgsbs_sp/712
dc.contributor.departmentGraduate School of Biomedical Sciences
dc.contributor.departmentDepartment of Cell Biology
dc.source.pages128-33


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