Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
Authors
Yang, HyekyungMustafa, Farah
Valsamakis, Alexandra
Santoro, Joseph C.
Griffin, Diane E.
Robinson, Harriet L.
Document Type
Journal ArticlePublication Date
1997-06-01Keywords
Animals; Antibodies, Viral; Biolistics; Cercopithecus aethiops; DNA, Viral; Enzyme-Linked Immunosorbent Assay; Measles Vaccine; Measles virus; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Rabbits; Vaccines, DNA; Vero CellsLife Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
DNA-mediated immunizations have been used to raise neutralizing antibodies for measles virus. Single inoculations of plasmids expressing measles hemagglutinin or fusion glycoproteins raised neutralizing antibody in BALB/c mice. Plasmids expressing the hemagglutinin glycoprotein (both normal and secreted) raised neutralizing responses that persisted for 1 year. For both forms of hemagglutinin, the effectiveness of the raised antibody (ratio of neutralizing activity to ELISA activity) was similar. High titers of neutralizing antibody were also raised by inoculation of rabbits with the hemagglutinin and fusion glycoprotein-expressing plasmids.Source
Vaccine. 1997 Jun;15(8):888-91.
DOI
10.1016/S0264-410X(96)00261-7Permanent Link to this Item
http://hdl.handle.net/20.500.14038/34088PubMed ID
9234540Related Resources
ae974a485f413a2113503eed53cd6c53
10.1016/S0264-410X(96)00261-7