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dc.contributor.authorYasutomi, Yasuhiro
dc.contributor.authorRobinson, Harriet L.
dc.contributor.authorLu, Shan
dc.contributor.authorMustafa, Farah
dc.contributor.authorLekutis, Christine
dc.contributor.authorArthos, James
dc.contributor.authorMullins, James I.
dc.contributor.authorVoss, Gerald
dc.contributor.authorManson, Kelledy
dc.contributor.authorWyand, Michael
dc.contributor.authorLetvin, Norman L.
dc.date2022-08-11T08:09:01.000
dc.date.accessioned2022-08-23T16:15:26Z
dc.date.available2022-08-23T16:15:26Z
dc.date.issued1996-01-01
dc.date.submitted2008-11-04
dc.identifier.citation<p>J Virol. 1996 Jan;70(1):678-81.</p>
dc.identifier.issn0022-538X (Print)
dc.identifier.pmid8523593
dc.identifier.urihttp://hdl.handle.net/20.500.14038/34089
dc.description.abstractIn view of the growing evidence that virus-specific cytotoxic T lymphocytes (CTL) play an important role in containing the early spread of human immunodeficiency virus type 1 (HIV-1) in infected individuals, novel vaccine strategies capable of eliciting HIV-1-specific CTL are being pursued in attempts to create an effective AIDS vaccine. We have used the simian immunodeficiency virus of macaques (SIVmac)/rhesus monkey model to explore the induction of AIDS virus-specific CTL responses by DNA vaccination. We found that the inoculation of rhesus monkeys with plasmid DNA encoding SIVmac Env and Gag elicited a persisting SIVmac-specific memory CTL response. These CTL were CD8+ and major histocompatibility complex class I restricted. These studies provide evidence for the potential utility of DNA inoculation as an approach to an HIV-1 vaccine.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=8523593&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC189866/
dc.subjectAnimals; DNA, Viral; Gene Products, env; Histocompatibility Antigens Class I; Macaca mulatta; Plasmids; Retroviridae Proteins; Simian immunodeficiency virus; T-Lymphocytes, Cytotoxic; Tumor Cells, Cultured; Vaccines, Synthetic; Viral Envelope Proteins; Viral Vaccines
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleSimian immunodeficiency virus-specific cytotoxic T-lymphocyte induction through DNA vaccination of rhesus monkeys
dc.typeJournal Article
dc.source.journaltitleJournal of virology
dc.source.volume70
dc.source.issue1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/754
dc.identifier.contextkey660873
html.description.abstract<p>In view of the growing evidence that virus-specific cytotoxic T lymphocytes (CTL) play an important role in containing the early spread of human immunodeficiency virus type 1 (HIV-1) in infected individuals, novel vaccine strategies capable of eliciting HIV-1-specific CTL are being pursued in attempts to create an effective AIDS vaccine. We have used the simian immunodeficiency virus of macaques (SIVmac)/rhesus monkey model to explore the induction of AIDS virus-specific CTL responses by DNA vaccination. We found that the inoculation of rhesus monkeys with plasmid DNA encoding SIVmac Env and Gag elicited a persisting SIVmac-specific memory CTL response. These CTL were CD8+ and major histocompatibility complex class I restricted. These studies provide evidence for the potential utility of DNA inoculation as an approach to an HIV-1 vaccine.</p>
dc.identifier.submissionpathgsbs_sp/754
dc.contributor.departmentDepartment of Pathology
dc.contributor.departmentDepartment of Medicine
dc.contributor.departmentGraduate School of Biomedical Sciences
dc.source.pages678-81


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