Simian immunodeficiency virus-specific cytotoxic T-lymphocyte induction through DNA vaccination of rhesus monkeys
dc.contributor.author | Yasutomi, Yasuhiro | |
dc.contributor.author | Robinson, Harriet L. | |
dc.contributor.author | Lu, Shan | |
dc.contributor.author | Mustafa, Farah | |
dc.contributor.author | Lekutis, Christine | |
dc.contributor.author | Arthos, James | |
dc.contributor.author | Mullins, James I. | |
dc.contributor.author | Voss, Gerald | |
dc.contributor.author | Manson, Kelledy | |
dc.contributor.author | Wyand, Michael | |
dc.contributor.author | Letvin, Norman L. | |
dc.date | 2022-08-11T08:09:01.000 | |
dc.date.accessioned | 2022-08-23T16:15:26Z | |
dc.date.available | 2022-08-23T16:15:26Z | |
dc.date.issued | 1996-01-01 | |
dc.date.submitted | 2008-11-04 | |
dc.identifier.citation | <p>J Virol. 1996 Jan;70(1):678-81.</p> | |
dc.identifier.issn | 0022-538X (Print) | |
dc.identifier.pmid | 8523593 | |
dc.identifier.uri | http://hdl.handle.net/20.500.14038/34089 | |
dc.description.abstract | In view of the growing evidence that virus-specific cytotoxic T lymphocytes (CTL) play an important role in containing the early spread of human immunodeficiency virus type 1 (HIV-1) in infected individuals, novel vaccine strategies capable of eliciting HIV-1-specific CTL are being pursued in attempts to create an effective AIDS vaccine. We have used the simian immunodeficiency virus of macaques (SIVmac)/rhesus monkey model to explore the induction of AIDS virus-specific CTL responses by DNA vaccination. We found that the inoculation of rhesus monkeys with plasmid DNA encoding SIVmac Env and Gag elicited a persisting SIVmac-specific memory CTL response. These CTL were CD8+ and major histocompatibility complex class I restricted. These studies provide evidence for the potential utility of DNA inoculation as an approach to an HIV-1 vaccine. | |
dc.language.iso | en_US | |
dc.relation | <p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=8523593&dopt=Abstract">Link to Article in PubMed</a></p> | |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC189866/ | |
dc.subject | Animals; DNA, Viral; Gene Products, env; Histocompatibility Antigens Class I; Macaca mulatta; Plasmids; Retroviridae Proteins; Simian immunodeficiency virus; T-Lymphocytes, Cytotoxic; Tumor Cells, Cultured; Vaccines, Synthetic; Viral Envelope Proteins; Viral Vaccines | |
dc.subject | Life Sciences | |
dc.subject | Medicine and Health Sciences | |
dc.title | Simian immunodeficiency virus-specific cytotoxic T-lymphocyte induction through DNA vaccination of rhesus monkeys | |
dc.type | Journal Article | |
dc.source.journaltitle | Journal of virology | |
dc.source.volume | 70 | |
dc.source.issue | 1 | |
dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/gsbs_sp/754 | |
dc.identifier.contextkey | 660873 | |
html.description.abstract | <p>In view of the growing evidence that virus-specific cytotoxic T lymphocytes (CTL) play an important role in containing the early spread of human immunodeficiency virus type 1 (HIV-1) in infected individuals, novel vaccine strategies capable of eliciting HIV-1-specific CTL are being pursued in attempts to create an effective AIDS vaccine. We have used the simian immunodeficiency virus of macaques (SIVmac)/rhesus monkey model to explore the induction of AIDS virus-specific CTL responses by DNA vaccination. We found that the inoculation of rhesus monkeys with plasmid DNA encoding SIVmac Env and Gag elicited a persisting SIVmac-specific memory CTL response. These CTL were CD8+ and major histocompatibility complex class I restricted. These studies provide evidence for the potential utility of DNA inoculation as an approach to an HIV-1 vaccine.</p> | |
dc.identifier.submissionpath | gsbs_sp/754 | |
dc.contributor.department | Department of Pathology | |
dc.contributor.department | Department of Medicine | |
dc.contributor.department | Graduate School of Biomedical Sciences | |
dc.source.pages | 678-81 |