Evolution of the CD8 T-cell repertoire during infections
| dc.contributor.author | Lin, Meei-Yun | |
| dc.contributor.author | Selin, Liisa K. | |
| dc.contributor.author | Welsh, Raymond M. | |
| dc.date | 2022-08-11T08:09:01.000 | |
| dc.date.accessioned | 2022-08-23T16:15:29Z | |
| dc.date.available | 2022-08-23T16:15:29Z | |
| dc.date.issued | 2000-09-01 | |
| dc.date.submitted | 2008-11-05 | |
| dc.identifier.citation | Microbes Infect. 2000 Jul;2(9):1025-39. | |
| dc.identifier.issn | 1286-4579 (Print) | |
| dc.identifier.pmid | 10967283 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14038/34100 | |
| dc.description.abstract | CD8 T cells exist in a dynamic network whose repertoire remains static in the absence of infection but changes in the presence of foreign antigens. Individuals each have unique T-cell repertoires that continually evolve in the presence of antigen and of cross-reactive heterologous antigens, and homeostatic forces drive deletions in T-cell memory pools to accommodate the entry of new memory cells into a finite immune system. | |
| dc.language.iso | en_US | |
| dc.relation | <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10967283&dopt=Abstract">Link to article in PubMed</a> | |
| dc.relation.url | http://dx.doi.org/10.1016/S1286-4579(00)01257-0 | |
| dc.subject | Animals; Antigens, Viral; CD8-Positive T-Lymphocytes; Epstein-Barr Virus Infections; Flow Cytometry; Herpesvirus 4, Human; Interferon Type II; Lymphocytic Choriomeningitis; Lymphocytic choriomeningitis virus; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Antigen, T-Cell, alpha-beta; Spleen; T-Lymphocyte Subsets; Virus Latency | |
| dc.subject | Life Sciences | |
| dc.subject | Medicine and Health Sciences | |
| dc.title | Evolution of the CD8 T-cell repertoire during infections | |
| dc.type | Journal Article | |
| dc.source.journaltitle | Microbes and infection / Institut Pasteur | |
| dc.source.volume | 2 | |
| dc.source.issue | 9 | |
| dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/gsbs_sp/764 | |
| dc.identifier.contextkey | 661873 | |
| html.description.abstract | <p>CD8 T cells exist in a dynamic network whose repertoire remains static in the absence of infection but changes in the presence of foreign antigens. Individuals each have unique T-cell repertoires that continually evolve in the presence of antigen and of cross-reactive heterologous antigens, and homeostatic forces drive deletions in T-cell memory pools to accommodate the entry of new memory cells into a finite immune system.</p> | |
| dc.identifier.submissionpath | gsbs_sp/764 | |
| dc.contributor.department | Pathology | |
| dc.source.pages | 1025-39 |