Attrition of bystander CD8 T cells during virus-induced T-cell and interferon responses
AuthorsMcNally, James M.
Zarozinski, Christopher C.
Lin, Meei Y.
Brehm, Michael A.
Chen, Hong D.
Welsh, Raymond M.
UMass Chan AffiliationsDepartment of Pathology
Program in Immunology and Virology
Graduate School of Biomedical Sciences
Document TypeJournal Article
KeywordsAdoptive Transfer; Animals; Antigens, CD44; CD8-Positive T-Lymphocytes; Immunologic Memory; Interferon Type II; Interferon-alpha; Interferon-beta; Killer Cells, Natural; Lymphocytic Choriomeningitis; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Perforin; Poly I-C; Pore Forming Cytotoxic Proteins; T-Lymphocytes
Medicine and Health Sciences
MetadataShow full item record
AbstractExperiments designed to distinguish virus-specific from non-virus-specific T cells showed that bystander T cells underwent apoptosis and substantial attrition in the wake of a strong T-cell response. Memory CD8 T cells (CD8(+) CD44(hi)) were most affected. During acute viral infection, transgenic T cells that were clearly defined as non-virus specific decreased in number and showed an increase in apoptosis. Also, use of lymphocytic choriomeningitis virus (LCMV) carrier mice, which lack LCMV-specific T cells, showed a significant decline in non-virus-specific memory CD8 T cells that correlated to an increase in apoptosis in response to the proliferation of adoptively transferred virus-specific T cells. Attrition of T cells early during infection correlated with the alpha/beta interferon (IFN-alpha/beta) peak, and the IFN inducer poly(I:C) caused apoptosis and attrition of CD8(+) CD44(hi) T cells in normal mice but not in IFN-alpha/beta receptor-deficient mice. Apoptotic attrition of bystander T cells may make room for the antigen-specific expansion of T cells during infection and may, in part, account for the loss of T-cell memory that occurs when the host undergoes subsequent infections.
SourceJ Virol. 2001 Jul;75(13):5965-76. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/34180
Related ResourcesLink to article in PubMed