New insights into the regulation and functions of Tec family tyrosine kinases in the immune system
UMass Chan AffiliationsDepartment of Pathology
Program in Immunology and Virology
Graduate School of Biomedical Sciences
Document TypeJournal Article
Keywords1-Phosphatidylinositol 3-Kinase; Animals; Apoptosis; Cell Differentiation; Enzyme Activation; Humans; Isoenzymes; Lymphocytes; Mice; Phospholipase C gamma; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Type C Phospholipases; src Homology Domains
Medicine and Health Sciences
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AbstractThe Tec family of protein tyrosine kinases play an important role in signaling through antigen-receptors such as the TCR, BCR and Fcepsilon receptor. Recent studies have generated new insights into the domains in Tec kinases that take part in intramolecular and intermolecular binding. Furthermore, the consequences of these domain interactions for Tec activation and downregulation have been better defined. Genetic studies of kinase-knockout mice have emphasized the importance of Tec kinases in lymphocyte development, differentiation and apoptosis.
Curr Opin Immunol. 2002 Jun;14(3):331-40.
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/34209