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dc.contributor.authorMiller, Andrew Todd
dc.contributor.authorBerg, Leslie J.
dc.date2022-08-11T08:09:02.000
dc.date.accessioned2022-08-23T16:15:56Z
dc.date.available2022-08-23T16:15:56Z
dc.date.issued2002-04-26
dc.date.submitted2008-11-21
dc.identifier.citation<p>Curr Opin Immunol. 2002 Jun;14(3):331-40.</p>
dc.identifier.issn0952-7915 (Print)
dc.identifier.doi10.1016/S0952-7915(02)00345-X
dc.identifier.pmid11973131
dc.identifier.urihttp://hdl.handle.net/20.500.14038/34209
dc.description.abstractThe Tec family of protein tyrosine kinases play an important role in signaling through antigen-receptors such as the TCR, BCR and Fcepsilon receptor. Recent studies have generated new insights into the domains in Tec kinases that take part in intramolecular and intermolecular binding. Furthermore, the consequences of these domain interactions for Tec activation and downregulation have been better defined. Genetic studies of kinase-knockout mice have emphasized the importance of Tec kinases in lymphocyte development, differentiation and apoptosis.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11973131&dopt=Abstract">Link to article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.1016/S0952-7915(02)00345-X
dc.subject1-Phosphatidylinositol 3-Kinase; Animals; Apoptosis; Cell Differentiation; Enzyme Activation; Humans; Isoenzymes; Lymphocytes; Mice; Phospholipase C gamma; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Type C Phospholipases; src Homology Domains
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleNew insights into the regulation and functions of Tec family tyrosine kinases in the immune system
dc.typeJournal Article
dc.source.journaltitleCurrent opinion in immunology
dc.source.volume14
dc.source.issue3
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/866
dc.identifier.contextkey670713
html.description.abstract<p>The Tec family of protein tyrosine kinases play an important role in signaling through antigen-receptors such as the TCR, BCR and Fcepsilon receptor. Recent studies have generated new insights into the domains in Tec kinases that take part in intramolecular and intermolecular binding. Furthermore, the consequences of these domain interactions for Tec activation and downregulation have been better defined. Genetic studies of kinase-knockout mice have emphasized the importance of Tec kinases in lymphocyte development, differentiation and apoptosis.</p>
dc.identifier.submissionpathgsbs_sp/866
dc.contributor.departmentDepartment of Pathology
dc.contributor.departmentProgram in Immunology and Virology
dc.contributor.departmentGaa
dc.contributor.departmentGraduate School of Biomedical Sciences
dc.source.pages331-40


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