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    A novel subfamily of zinc finger genes involved in embryonic development

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    Authors
    Nakamura, Mako
    Runko, Alexander Peter
    Sagerstrom, Charles G.
    UMass Chan Affiliations
    Department of Biochemistry and Molecular Pharmacology
    Graduate School of Biomedical Sciences
    Document Type
    Journal Article
    Publication Date
    2004-09-28
    Keywords
    Animals; Embryo, Mammalian; *Embryo, Nonmammalian; Gene Expression Regulation, Developmental; *Morphogenesis; Multigene Family; Nuclear Proteins; Phylogeny; Transcription Factors; Zinc Fingers
    Life Sciences
    Medicine and Health Sciences
    
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    Link to Full Text
    http://dx.doi.org/10.1002/jcb.20255
    Abstract
    C2H2 zinc finger proteins make up one of the largest protein families in eukaryotic organisms. Recent study in several different systems has identified a set of novel zinc finger proteins that appear to form a distinct subfamily that we have named the NET family. Members of the NET family (Noc, Nlz, Elbow, and Tlp-1) share two protein motifs--a buttonhead box and an Sp motif--with zinc finger proteins from the Sp family. However, the NET family is uniquely characterized by a single atypical C2H2 zinc finger, in contrast to the Sp family that contains three tandem C2H2 fingers. Here, we review current information about the biochemical function and in vivo role for members of this subfamily. In general, NET family proteins are required during embryonic development. They appear to act by regulating transcription, most likely as repressors, although they are unlikely to bind DNA directly. In the future, it will be important to directly test if NET family proteins control transcription of specific target genes, perhaps via interactions with DNA-binding transcription factors, as well as to further explore their function in vivo.
    Source
    J Cell Biochem. 2004 Nov 15;93(5):887-95. Link to article on publisher's site
    DOI
    10.1002/jcb.20255
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/34240
    PubMed ID
    15449319
    Related Resources
    Link to article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1002/jcb.20255
    Scopus Count
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    Morningside Graduate School of Biomedical Sciences Scholarly Publications

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