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    Antiviral effect of lymphokine-activated killer cells: chemotaxis and homing to sites of virus infection

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    Authors
    Natuk, Robert J.
    Bukowski, Jack F.
    Brubaker, Jeffery O.
    Welsh, Raymond M.
    UMass Chan Affiliations
    Department of Pathology
    Graduate School of Biomedical Sciences
    Document Type
    Journal Article
    Publication Date
    1989-11-01
    Keywords
    Animals; Cells, Cultured; *Chemotaxis, Leukocyte; Interferon Type I; Interleukin-2; Killer Cells, Lymphokine-Activated; Mice; Mice, Inbred C57BL; Recombinant Proteins; Spleen; Vaccinia virus
    Life Sciences
    Medicine and Health Sciences
    
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC251148/
    Abstract
    Lymphokine-activated killer (LAK) cells generated from C57BL/6 mouse spleen cells cultured with interleukin-2 are effective prophylactically against virus infection when inoculated at the site of virus injection. To predict the therapeutic efficacy of LAK cells, we determined whether LAK cells would home to sites of virus infection. In vitro, LAK cells responded chemotactically to cell-free peritoneal exudate fluids collected from virus-infected mice and to preparations of purified beta interferon. In vivo, radiolabeled LAK cells injected intravenously accumulated in the peritoneal cavities of intraperitoneally infected mice in amounts three to eight times greater than in uninfected mice. This ability to respond to chemotactic agents and migrate into sites of virus infection may make LAK cells useful as antiviral therapeutic agents.
    Source

    J Virol. 1989 Nov;63(11):4969-71.

    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/34243
    PubMed ID
    2795722
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