Arachidonic acid and other fatty acids directly activate potassium channels in smooth muscle cells
Document Type
Journal ArticlePublication Date
1989-06-09Keywords
Animals; Arachidonic Acid; Arachidonic Acids; Bufo marinus; Fatty Acids, Nonesterified; Ion Channels; Kinetics; Membrane Potentials; Muscle, Smooth; StomachLife Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Arachidonic acid, as well as fatty acids that are not substrates for cyclooxygenase and lipoxygenase enzymes, activated a specific type of potassium channel in freshly dissociated smooth muscle cells. Activation occurred in excised membrane patches in the absence of calcium and all nucleotides. Therefore signal transduction pathways that require such soluble factors, including the NADPH-dependent cytochrome P450 pathway, do not mediate the response. Thus, fatty acids directly activate potassium channels and so may constitute a class of signal molecules that regulate ion channels.Source
Science. 1989 Jun 9;244(4909):1176-9.
DOI
10.1126/science.2471269Permanent Link to this Item
http://hdl.handle.net/20.500.14038/34270PubMed ID
2471269Related Resources
ae974a485f413a2113503eed53cd6c53
10.1126/science.2471269