SRC-1 and Wnt signaling act together to specify endoderm and to control cleavage orientation in early C. elegans embryos
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Journal ArticlePublication Date
2002-07-12Keywords
Animals; Body Patterning; Caenorhabditis elegans; *Caenorhabditis elegans Proteins; Cell Division; Cell Lineage; Cell Polarity; DNA-Binding Proteins; Embryo, Nonmammalian; Endoderm; Gene Expression Regulation, Developmental; Helminth Proteins; High Mobility Group Proteins; Molecular Sequence Data; Phosphotyrosine; Proto-Oncogene Proteins; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Signal Transduction; Wnt Proteins; *Zebrafish Proteins; src-Family KinasesLife Sciences
Medicine and Health Sciences
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In early C. elegans embryos, signaling between a posterior blastomere, P2, and a ventral blastomere, EMS, specifies endoderm and orients the division axis of the EMS cell. Although Wnt signaling contributes to this polarizing interaction, no mutants identified to date abolish P2/EMS signaling. Here, we show that two tyrosine kinase-related genes, src-1 and mes-1, are required for the accumulation of phosphotyrosine between P2 and EMS. Moreover, src-1 and mes-1 mutants strongly enhance endoderm and EMS spindle rotation defects associated with Wnt pathway mutants. SRC-1 and MES-1 signal bidirectionally to control cell fate and division orientation in both EMS and P2. Our findings suggest that Wnt and Src signaling function in parallel to control developmental outcomes within a single responding cell.Source
Dev Cell. 2002 Jul;3(1):113-25.
DOI
10.1016/S1534-5807(02)00185-5Permanent Link to this Item
http://hdl.handle.net/20.500.14038/34276PubMed ID
12110172Related Resources
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