Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
UMass Chan Affiliations
Department of PhysiologyDepartment of Molecular Genetics and Microbiology
Graduate School of Biomedical Sciences
Document Type
Journal ArticlePublication Date
2005-04-14Keywords
Animals; B-Lymphocytes; *Homeostasis; Humans; Immunologic Memory; *Lymphocyte Activation; MiceLife Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Naive B cells introduced into a lymphopenic host undergo antigen-independent proliferation which is inhibited in a cell dose dependent manner by feedback from mature B cells. Homeostatic proliferation is a generalized lymphocyte property with B cells sharing many of the inductive and regulatory characteristics established for naive and memory CD4+ and CD8+ T cells and NK cells. In this communication we discuss the cytokine requirements for B cell HP, extend the murine studies to human cells, and propose the hypothesis that B cell HP may provide an antigen-independent mechanism for maintaining B cell memory.Source
Semin Immunol. 2005 Jun;17(3):209-17. Link to article on publisher's siteDOI
10.1016/j.smim.2005.02.006Permanent Link to this Item
http://hdl.handle.net/20.500.14038/34289PubMed ID
15826826Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.smim.2005.02.006