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UMass Chan Affiliations
Department of PhysiologyDepartment of Molecular Genetics and Microbiology
Graduate School of Biomedical Sciences
Document Type
Journal ArticlePublication Date
2006-08-26Keywords
Alternative Splicing; Animals; Apoptosis; B-Cell Activating Factor; B-Cell Activation Factor Receptor; B-Cell Maturation Antigen; B-Lymphocyte Subsets; Cell Survival; Homeostasis; Humans; Immunoglobulin Class Switching; Lymphoma, B-Cell; Mice; Mice, Inbred A; Models, Immunological; Neoplasm Proteins; Protein Kinases; Recombinant Fusion Proteins; Signal Transduction; Transcription Factors; Transfection; Transmembrane Activator and CAML Interactor Protein; Tumor Necrosis Factor Ligand Superfamily Member 13Life Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Naive peripheral B cells survive in vivo because of active stimulation by the TNF superfamily ligand B lymphocyte stimulator (BLyS/BAFF). Although the survival promoting properties of BLyS are well known, the signal pathways and molecular effectors that characterize this stimulation are still being elucidated. In this communication, we discuss the signal cascades that effect BLyS dependent survival and the regulation of BLyS induced signaling. We also examine the role of BLyS as a growth factor and propose that BLyS induced metabolic enhancement optimizes the B cell response to BCR and TLR-dependent signaling.Source
Semin Immunol. 2006 Oct;18(5):318-26. Epub 2006 Aug 22. Link to article on publisher's siteDOI
10.1016/j.smim.2006.06.001Permanent Link to this Item
http://hdl.handle.net/20.500.14038/34292PubMed ID
16931037Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.smim.2006.06.001