BLyS and B cell homeostasis

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Authors
Woodland, Robert T.
Schmidt, Madelyn R.
Thompson, Craig B.
UMass Chan Affiliations
Department of Physiology
Department of Molecular Genetics and Microbiology
Graduate School of Biomedical Sciences
Document Type
Journal Article
Publication Date
2006-08-26
Keywords
Alternative Splicing; Animals; Apoptosis; B-Cell Activating Factor; B-Cell Activation Factor Receptor; B-Cell Maturation Antigen; B-Lymphocyte Subsets; Cell Survival; Homeostasis; Humans; Immunoglobulin Class Switching; Lymphoma, B-Cell; Mice; Mice, Inbred A; Models, Immunological; Neoplasm Proteins; Protein Kinases; Recombinant Fusion Proteins; Signal Transduction; Transcription Factors; Transfection; Transmembrane Activator and CAML Interactor Protein; Tumor Necrosis Factor Ligand Superfamily Member 13
Life Sciences
Medicine and Health Sciences

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Link to Full Text
http://dx.doi.org/10.1016/j.smim.2006.06.001
Abstract
Naive peripheral B cells survive in vivo because of active stimulation by the TNF superfamily ligand B lymphocyte stimulator (BLyS/BAFF). Although the survival promoting properties of BLyS are well known, the signal pathways and molecular effectors that characterize this stimulation are still being elucidated. In this communication, we discuss the signal cascades that effect BLyS dependent survival and the regulation of BLyS induced signaling. We also examine the role of BLyS as a growth factor and propose that BLyS induced metabolic enhancement optimizes the B cell response to BCR and TLR-dependent signaling.
Source
Semin Immunol. 2006 Oct;18(5):318-26. Epub 2006 Aug 22. Link to article on publisher's site
DOI
10.1016/j.smim.2006.06.001
Permanent Link to this Item
http://hdl.handle.net/20.500.14038/34292
PubMed ID
16931037
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