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    BLyS and B cell homeostasis

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    Authors
    Woodland, Robert T.
    Schmidt, Madelyn R.
    Thompson, Craig B.
    UMass Chan Affiliations
    Department of Physiology
    Department of Molecular Genetics and Microbiology
    Graduate School of Biomedical Sciences
    Document Type
    Journal Article
    Publication Date
    2006-08-26
    Keywords
    Alternative Splicing; Animals; Apoptosis; B-Cell Activating Factor; B-Cell Activation Factor Receptor; B-Cell Maturation Antigen; B-Lymphocyte Subsets; Cell Survival; Homeostasis; Humans; Immunoglobulin Class Switching; Lymphoma, B-Cell; Mice; Mice, Inbred A; Models, Immunological; Neoplasm Proteins; Protein Kinases; Recombinant Fusion Proteins; Signal Transduction; Transcription Factors; Transfection; Transmembrane Activator and CAML Interactor Protein; Tumor Necrosis Factor Ligand Superfamily Member 13
    Life Sciences
    Medicine and Health Sciences
    
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    http://dx.doi.org/10.1016/j.smim.2006.06.001
    Abstract
    Naive peripheral B cells survive in vivo because of active stimulation by the TNF superfamily ligand B lymphocyte stimulator (BLyS/BAFF). Although the survival promoting properties of BLyS are well known, the signal pathways and molecular effectors that characterize this stimulation are still being elucidated. In this communication, we discuss the signal cascades that effect BLyS dependent survival and the regulation of BLyS induced signaling. We also examine the role of BLyS as a growth factor and propose that BLyS induced metabolic enhancement optimizes the B cell response to BCR and TLR-dependent signaling.
    Source
    Semin Immunol. 2006 Oct;18(5):318-26. Epub 2006 Aug 22. Link to article on publisher's site
    DOI
    10.1016/j.smim.2006.06.001
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/34292
    PubMed ID
    16931037
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.smim.2006.06.001
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    Morningside Graduate School of Biomedical Sciences Scholarly Publications

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