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    Th1 genetic adjuvants modulate immune responses in neonates

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    Authors
    Pertmer, Tamera Marie
    Oran, Alp E.
    Madorin, Catherine A.
    Robinson, Harriet L.
    UMass Chan Affiliations
    Program in Immunology and Virology
    Graduate School of Biomedical Sciences
    Document Type
    Journal Article
    Publication Date
    2001-02-13
    Keywords
    Adjuvants, Immunologic; Aging; Animals; Animals, Newborn; Enzyme-Linked Immunosorbent Assay; Hemagglutinin Glycoproteins, Influenza Virus; Immunoglobulin G; Immunoglobulin Isotypes; Interferon Type II; Interleukin-12; Interleukin-5; Mice; Mice, Inbred BALB C; Spleen; Th1 Cells; Vaccination; Vaccines, DNA
    Life Sciences
    Medicine and Health Sciences
    
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    https://doi.org/10.1016/S0264-410X(00)00388-1
    Abstract
    In these studies, we address the ability of DNA encoding Th1 cytokines to bias the isotype of antibody raised by neonatal or adult immunization with an influenza hemagglutinin expressing DNA (HA-DNA). Neonatal mice coimmunized with HA-DNA and either IL-12 or IFN-gamma-expressing DNA developed IgG2a-biased immune responses, regardless of inoculation method. In contrast, the Th1 genetic adjuvants had no effect on IgG subtype patterns in adults. In neonatal mice, the Th1 genetic adjuvants also shifted the pattern of lymphokine production by recall splenocytes from a mixed response of IFN-gamma and IL-5 to exclusively IFN-gamma. In adults, despite the failure to change the isotype pattern of the antibody response, a shift towards IFN-gamma production also occurred for recall splenocytes following coimmunzation with IL-12. Thus, coinoculation of Th1 genetic adjuvants had greater effects on the nature of the immune response in the neonate than in adults.
    Source

    Vaccine. 2001 Feb 8;19(13-14):1764-71.

    DOI
    10.1016/S0264-410X(00)00388-1
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/34332
    PubMed ID
    11166902
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    ae974a485f413a2113503eed53cd6c53
    10.1016/S0264-410X(00)00388-1
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