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    Direct effects of fatty acids and other charged lipids on ion channel activity in smooth muscle cells

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    Authors
    Petrou, Steven
    Ordway, Richard W.
    Kirber, Michael T.
    Dopico, Alejandro M.
    Hamilton, James A.
    Walsh, John V.
    Singer, Joshua J.
    UMass Chan Affiliations
    Department of Physiology
    Graduate School of Biomedical Sciences
    Document Type
    Journal Article
    Publication Date
    1995-02-01
    Keywords
    Acyl Coenzyme A; Animals; Bufo marinus; Fatty Acids; Models, Biological; Muscle, Smooth; Patch-Clamp Techniques; Physical Stimulation; Potassium Channels; Stimulation, Chemical; Stomach
    Life Sciences
    Medicine and Health Sciences
    
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    Link to Full Text
    http://dx.doi.org/10.1016/0952-3278(95)90018-7
    Abstract
    A variety of fatty acids increase the activity of certain types of K+ channels. This effect is not dependent on the three enzymatic pathways that convert arachidonic acid to various bioactive oxygenated metabolites. One type of K+ channel in toad stomach smooth muscle cell membranes in activated by fatty acids and other single chain lipids which possess both a negatively charged head group and a sufficiently hydrophobic acyl chain. Neutral lipids have no effect on K+ channel activity, while positively charged lipids with a sufficiently hydrophobic acyl chain suppress channel activity. Acyl Coenzyme A's, which do not flip across the bilayer, act only from the cytosolic surface of the membrane, suggesting that the binding site for channel activation is also located there. This fatty acid-activated channel is also activated by membrane stretch. Moreover, this mechanical response is either mediated or modulated by fatty acids. Thus, fatty acids and other charged single chain lipids may comprise another class of first or second messenger molecules that target ion channels.
    Source
    Prostaglandins Leukot Essent Fatty Acids. 1995 Feb-Mar;52(2-3):173-8.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/34336
    PubMed ID
    7784455
    Related Resources
    Link to article in PubMed
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    Morningside Graduate School of Biomedical Sciences Scholarly Publications

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