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    Alendronate improves bone mineral density in perinatally HIV-infected children and adolescents with low bone mineral density for age

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    Authors
    Jacobson, D. L.
    Lindsey, J. C.
    Gordon, C.
    Hazra, R.
    Spiegel, H.
    Ferreira, F.
    Amaral, F. R.
    Pagano-Therrien, Jesica
    Gaur, A.
    George, K.
    Benson, J.
    Siberry, G. K.
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    UMass Chan Affiliations
    Graduate School of Nursing
    Document Type
    Journal Article
    Publication Date
    2019-10-01
    Keywords
    HIV-infection
    alendronate
    children
    low bone mineral density
    Immune System Diseases
    Infectious Disease
    Musculoskeletal Diseases
    Musculoskeletal, Neural, and Ocular Physiology
    Musculoskeletal System
    Nutritional and Metabolic Diseases
    Pediatrics
    Virus Diseases
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    Link to Full Text
    https://doi.org/10.1093/cid/ciz957
    Abstract
    BACKGROUND: Perinatally HIV-infected (PHIV) children and adolescents with low bone mineral density (BMD) may be at higher risk of osteoporosis and fractures in later life than their uninfected peers. Bisphosphonate therapy has been shown to reduce fractures in adults with osteoporosis, but has not been formally studied in HIV-infected youth. METHODS: Fifty-two PHIV 11- < 25 years of age with low lumbar spine (LS) BMD (Z-score < -1.5) were randomized to receive once-weekly alendronate or placebo in a double-blind cross-over study designed to assess the safety and efficacy of 48 and 96 weeks of alendronate in the US and Brazil (ClinicalTrials.gov # NCT000921557). All participants received daily calcium carbonate and vitamin D supplementation and were asked to engage in regular weight-bearing exercise. Safety and efficacy are summarized for the initial 48 weeks of the trial. RESULTS: Grade > /= 3 abnormal laboratory values, signs, or symptoms developed in 5 of 32 (16%) participants on alendronate and 2 of 18 (11%) on placebo (p > 0.99). No cases of jaw osteonecrosis, atrial fibrillation, or non-healing fractures were reported. Mean increases (95% confidence interval) in LS BMD over 48 weeks were significantly larger on alendronate [20% (14%, 25%)] than placebo [7% (5%, 9%), p < 0.001]. Similar improvements were seen for whole body BMD. CONCLUSIONS: In this small study in PHIV children and adolescents with low LS BMD, 48 weeks of alendronate was well-tolerated, showed no safety concerns, and significantly improved LS and whole body BMD compared to participants on vitamin D/calcium supplementation and exercise alone.
    Source

    Jacobson DL, Lindsey JC, Gordon C, Hazra R, Spiegel H, Ferreira F, Amaral FR, Pagano-Therrien J, Gaur A, George K, Benson J, Siberry GK; IMPAACT P1076 Study Team. Alendronate improves bone mineral density in perinatally HIV-infected children and adolescents with low bone mineral density for age. Clin Infect Dis. 2019 Oct 1;ciz957. doi: 10.1093/cid/ciz957. [Epub ahead of print]. PMID: 31573608. Link to article on publisher's site

    DOI
    10.1093/cid/ciz957
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/34450
    PubMed ID
    31573608
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    ae974a485f413a2113503eed53cd6c53
    10.1093/cid/ciz957
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