The impact of breast cancer on physical activity from midlife to early older adulthood and predictors of change post-diagnosis
AuthorsPettee Gabriel, Kelley
Colvin, Alicia B.
Lucas, Alexander R.
Karvonen-Gutierrez, Carrie A.
Gold, Ellen B.
Crawford, Sybil L.
Greendale, Gail A.
Avis, Nancy E.
UMass Chan AffiliationsGraduate School of Nursing
Psychiatry and Psychology
Skin and Connective Tissue Diseases
MetadataShow full item record
AbstractPURPOSE: To examine physical activity (PA) patterns from pre- to post-diagnosis, and compare these changes to women without breast cancer. To determine pre-diagnosis predictors of PA change, post-diagnosis, in breast cancer survivors (BCS). METHODS: Data were from 2314 Study of Women's Health Across the Nation (SWAN) participants, average age of 46.4 +/- 2.7 years at baseline (1996-1997). In Pink SWAN, 151 women who reported an incident breast cancer diagnosis over 20 years were classified as BCS; the remaining 2163 women were controls. LOESS plots and linear mixed models were used to illustrate and compare PA changes (sports/exercise [primary measure] and total PA) from pre- to post-diagnosis (or corresponding period) in BCS versus controls. Adjusted linear regression models were used to determine pre-diagnosis predictors of at-risk post-diagnosis PA change patterns (consistently low and decreased PA). RESULTS: No differences in pre- to post-diagnosis PA (or corresponding period) were observed in BCS versus controls. Among BCS, the odds of at-risk post-diagnosis PA change patterns was 2.50 (95% CI 0.96-6.48) times higher for those who reported sleep problems at > /= 50% (compared to 0%) of pre-diagnosis visits and 3.49 (95% CI 1.26-9.65) times higher for those who were overweight or obese at all (compared to no) pre-diagnosis visits. No other statistically significant predictors were noted. CONCLUSIONS: Age-related declines in PA were not amplified by a breast cancer diagnosis. Given the beneficial role of PA across the cancer control continuum, efforts to increase or maintain adequate PA, post-diagnosis, should be continued. IMPLICATIONS FOR CANCER SURVIVORS: While age-related physical activity declines were not amplified breast cancer diagnosis, efforts to identify breast cancer survivors at increased risk for post-diagnosis physical activity declines (or maintenance of low activity) may be a high-yield strategy to improve prognosis and quality of life.
Pettee Gabriel K, Sternfeld B, Colvin AB, Lucas AR, Karvonen-Gutierrez CA, Gold EB, Crawford S, Greendale GA, Avis NE. The impact of breast cancer on physical activity from midlife to early older adulthood and predictors of change post-diagnosis. J Cancer Surviv. 2020 Aug;14(4):545-555. doi: 10.1007/s11764-020-00879-7. Epub 2020 Mar 30. PMID: 32232722; PMCID: PMC7365759. Link to article on publisher's site