HDL (High-Density Lipoprotein) Subclasses, Lipid Content, and Function Trajectories Across the Menopause Transition: SWAN-HDL Study
Authors
El Khoudary, Samar R.Chen, Xirun
Nasr, Alexis
Billheimer, Jeff
Brooks, Maria Mori
McConnell, Dan
Orchard, Trevor
Crawford, Sybil L.
Matthews, Karen A.
Rader, Daniel J.
UMass Chan Affiliations
Graduate School of NursingDocument Type
Journal ArticlePublication Date
2020-12-03Keywords
climactericlipoproteins
menopause
postmenopause
risk factors
Amino Acids, Peptides, and Proteins
Endocrinology, Diabetes, and Metabolism
Lipids
Physiology
Reproductive and Urinary Physiology
Women's Health
Metadata
Show full item recordAbstract
OBJECTIVE: The cardioprotective capacity of HDL (high-density lipoprotein) cholesterol postmenopause has been challenged. HDL subclasses, lipid contents, and function might be better predictors of cardiovascular risk than HDL cholesterol. Changes in these measures have not been characterized over the menopause transition (MT) with respect to timing relative to the final menstrual period. Approach and Results: Four hundred seventy-one women with HDL particle (HDL-P) subclasses (nuclear magnetic resonance spectroscopy total, large, medium, and small HDL-P and HDL size), HDL lipid content (HDL phospholipids and triglycerides), and HDL function (cholesterol efflux capacity [HDL-CEC]) measured for a maximum of 5 time points across the MT were included. HDL cholesterol and total HDL-P increased across the MT. Within the 1 to 2 years bracketing the final menstrual period, large HDL-P and HDL size declined while small HDL-P and HDL-triglyceride increased. Although overall HDL-CEC increased across the MT, HDL-CEC per HDL-P declined. Higher concentrations of total, large, and medium HDL-P and greater HDL size were associated with greater HDL-CEC while of small HDL-P were associated with lower HDL-CEC. Associations of large HDL-P and HDL size with HDL-CEC varied significantly across the MT such that higher large HDL-P concentrations and greater HDL size were associated with lower HDL-CEC within the 1 to 2 years around the final menstrual period. CONCLUSIONS: Although HDL cholesterol increased over the MT, HDL subclasses and lipid content showed adverse changes. While overall HDL-CEC increased, HDL-CEC per HDL-P declined, consistent with reduced function per particle. Large HDL-P may become less efficient in promoting HDL-CEC during the MT.Source
El Khoudary SR, Chen X, Nasr A, Billheimer J, Brooks MM, McConnell D, Orchard T, Crawford S, Matthews KA, Rader DJ. HDL (High-Density Lipoprotein) Subclasses, Lipid Content, and Function Trajectories Across the Menopause Transition: SWAN-HDL Study. Arterioscler Thromb Vasc Biol. 2020 Dec 3:ATVBAHA120315355. doi: 10.1161/ATVBAHA.120.315355. Epub ahead of print. PMID: 33267661. Link to article on publisher's site
DOI
10.1161/ATVBAHA.120.315355Permanent Link to this Item
http://hdl.handle.net/20.500.14038/34471PubMed ID
33267661Related Resources
ae974a485f413a2113503eed53cd6c53
10.1161/ATVBAHA.120.315355