• Login
    View Item 
    •   Home
    • UMass Chan Student Research and Publications
    • Tan Chingfen Graduate School of Nursing
    • Tan Chingfen Graduate School of Nursing Scholarly Publications
    • View Item
    •   Home
    • UMass Chan Student Research and Publications
    • Tan Chingfen Graduate School of Nursing
    • Tan Chingfen Graduate School of Nursing Scholarly Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of eScholarship@UMassChanCommunitiesPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywordsThis CollectionPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywords

    My Account

    LoginRegister

    Help

    AboutSubmission GuidelinesData Deposit PolicySearchingAccessibilityTerms of UseWebsite Migration FAQ

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    HDL (High-Density Lipoprotein) Subclasses, Lipid Content, and Function Trajectories Across the Menopause Transition: SWAN-HDL Study

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    El Khoudary, Samar R.
    Chen, Xirun
    Nasr, Alexis
    Billheimer, Jeff
    Brooks, Maria Mori
    McConnell, Dan
    Orchard, Trevor
    Crawford, Sybil L.
    Matthews, Karen A.
    Rader, Daniel J.
    UMass Chan Affiliations
    Graduate School of Nursing
    Document Type
    Journal Article
    Publication Date
    2020-12-03
    Keywords
    climacteric
    lipoproteins
    menopause
    postmenopause
    risk factors
    Amino Acids, Peptides, and Proteins
    Endocrinology, Diabetes, and Metabolism
    Lipids
    Physiology
    Reproductive and Urinary Physiology
    Women's Health
    Show allShow less
    
    Metadata
    Show full item record
    Link to Full Text
    https://doi.org/10.1161/atvbaha.120.315355
    Abstract
    OBJECTIVE: The cardioprotective capacity of HDL (high-density lipoprotein) cholesterol postmenopause has been challenged. HDL subclasses, lipid contents, and function might be better predictors of cardiovascular risk than HDL cholesterol. Changes in these measures have not been characterized over the menopause transition (MT) with respect to timing relative to the final menstrual period. Approach and Results: Four hundred seventy-one women with HDL particle (HDL-P) subclasses (nuclear magnetic resonance spectroscopy total, large, medium, and small HDL-P and HDL size), HDL lipid content (HDL phospholipids and triglycerides), and HDL function (cholesterol efflux capacity [HDL-CEC]) measured for a maximum of 5 time points across the MT were included. HDL cholesterol and total HDL-P increased across the MT. Within the 1 to 2 years bracketing the final menstrual period, large HDL-P and HDL size declined while small HDL-P and HDL-triglyceride increased. Although overall HDL-CEC increased across the MT, HDL-CEC per HDL-P declined. Higher concentrations of total, large, and medium HDL-P and greater HDL size were associated with greater HDL-CEC while of small HDL-P were associated with lower HDL-CEC. Associations of large HDL-P and HDL size with HDL-CEC varied significantly across the MT such that higher large HDL-P concentrations and greater HDL size were associated with lower HDL-CEC within the 1 to 2 years around the final menstrual period. CONCLUSIONS: Although HDL cholesterol increased over the MT, HDL subclasses and lipid content showed adverse changes. While overall HDL-CEC increased, HDL-CEC per HDL-P declined, consistent with reduced function per particle. Large HDL-P may become less efficient in promoting HDL-CEC during the MT.
    Source

    El Khoudary SR, Chen X, Nasr A, Billheimer J, Brooks MM, McConnell D, Orchard T, Crawford S, Matthews KA, Rader DJ. HDL (High-Density Lipoprotein) Subclasses, Lipid Content, and Function Trajectories Across the Menopause Transition: SWAN-HDL Study. Arterioscler Thromb Vasc Biol. 2020 Dec 3:ATVBAHA120315355. doi: 10.1161/ATVBAHA.120.315355. Epub ahead of print. PMID: 33267661. Link to article on publisher's site

    DOI
    10.1161/ATVBAHA.120.315355
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/34471
    PubMed ID
    33267661
    Related Resources

    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1161/ATVBAHA.120.315355
    Scopus Count
    Collections
    Tan Chingfen Graduate School of Nursing Scholarly Publications

    entitlement

    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Lamar Soutter Library, UMass Chan Medical School | 55 Lake Avenue North | Worcester, MA 01655 USA
    Quick Guide | escholarship@umassmed.edu
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.