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dc.contributor.authorAvis, Nancy E.
dc.contributor.authorLevine, Beverly
dc.contributor.authorGoyal, Neha
dc.contributor.authorCrawford, Sybil L.
dc.contributor.authorHess, Rachel
dc.contributor.authorColvin, Alicia
dc.contributor.authorBromberger, Joyce T.
dc.contributor.authorGreendale, Gail A.
dc.date2022-08-11T08:09:04.000
dc.date.accessioned2022-08-23T16:17:04Z
dc.date.available2022-08-23T16:17:04Z
dc.date.issued2020-05-15
dc.date.submitted2021-02-25
dc.identifier.citation<p>Avis NE, Levine B, Goyal N, Crawford SL, Hess R, Colvin A, Bromberger JT, Greendale GA. Health-related quality of life among breast cancer survivors and noncancer controls over 10 years: Pink SWAN. Cancer. 2020 May 15;126(10):2296-2304. doi: 10.1002/cncr.32757. Epub 2020 Feb 27. PMID: 32105350. <a href="https://doi.org/10.1002/cncr.32757">Link to article on publisher's site</a></p>
dc.identifier.issn0008-543X (Linking)
dc.identifier.doi10.1002/cncr.32757
dc.identifier.pmid32105350
dc.identifier.urihttp://hdl.handle.net/20.500.14038/34472
dc.description.abstractBACKGROUND: The goal of this study was to compare health-related quality of life (HRQL) from diagnosis to 10 years postdiagnosis among breast cancer survivors (BCS) and women without cancer over the same period and to identify BCS subgroups exhibiting different HRQL trajectories. METHODS: Our analysis included 141 BCS and 2086 controls from the Study of Women's Health Across the Nation (SWAN), a multiracial/ethnic cohort study of mid-life women assessed approximately annually from 1995 to 2015. Pink SWAN participants reported no cancer at SWAN enrollment and developed (cases) or did not develop (controls) incident breast cancer after enrollment. We assessed HRQL with SF-36 Mental Component Summary and Physical Component Summary scores. We modeled each as a function of case/control status, years since diagnosis, years since diagnosis squared, and the interaction terms between case/control status and the 2 time variables in linear models. We characterized heterogeneity in postdiagnosis HRQL of cases using group-based trajectories. RESULTS: BCS had significantly lower HRQL compared with controls at diagnosis and 1 year postdiagnosis. By 2 years, BCS and controls no longer differed significantly. Among BCS, 2 trajectory groups were identified for both scores. For the Mental Component Summary, 88.4% of BCS had consistently good and 11.6% had very low scores. For the Physical Component Summary, 73.9% had good scores, and 26.1% had consistently low scores. Prediagnosis perceived stress and current smoking were related to being in the low mental trajectory group, and a higher number of comorbidities was related to being in the low physical trajectory group. CONCLUSION: Although the majority of BCS have HRQL similar to non-cancer controls after 2 years, subgroups of BCS continue to have low HRQL. Prediagnosis stress, comorbidities, and smoking are vulnerability factors for long-term, low HRQL in BCS.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=32105350&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.1002/cncr.32757
dc.subjectbreast
dc.subjectcancer
dc.subjecthealth-related quality of life
dc.subjectlongitudinal
dc.subjectsurvivors
dc.subjectEpidemiology
dc.subjectNeoplasms
dc.subjectOncology
dc.subjectWomen's Health
dc.titleHealth-related quality of life among breast cancer survivors and noncancer controls over 10 years: Pink SWAN
dc.typeJournal Article
dc.source.journaltitleCancer
dc.source.volume126
dc.source.issue10
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsn_pp/145
dc.identifier.contextkey21823465
html.description.abstract<p>BACKGROUND: The goal of this study was to compare health-related quality of life (HRQL) from diagnosis to 10 years postdiagnosis among breast cancer survivors (BCS) and women without cancer over the same period and to identify BCS subgroups exhibiting different HRQL trajectories.</p> <p>METHODS: Our analysis included 141 BCS and 2086 controls from the Study of Women's Health Across the Nation (SWAN), a multiracial/ethnic cohort study of mid-life women assessed approximately annually from 1995 to 2015. Pink SWAN participants reported no cancer at SWAN enrollment and developed (cases) or did not develop (controls) incident breast cancer after enrollment. We assessed HRQL with SF-36 Mental Component Summary and Physical Component Summary scores. We modeled each as a function of case/control status, years since diagnosis, years since diagnosis squared, and the interaction terms between case/control status and the 2 time variables in linear models. We characterized heterogeneity in postdiagnosis HRQL of cases using group-based trajectories.</p> <p>RESULTS: BCS had significantly lower HRQL compared with controls at diagnosis and 1 year postdiagnosis. By 2 years, BCS and controls no longer differed significantly. Among BCS, 2 trajectory groups were identified for both scores. For the Mental Component Summary, 88.4% of BCS had consistently good and 11.6% had very low scores. For the Physical Component Summary, 73.9% had good scores, and 26.1% had consistently low scores. Prediagnosis perceived stress and current smoking were related to being in the low mental trajectory group, and a higher number of comorbidities was related to being in the low physical trajectory group.</p> <p>CONCLUSION: Although the majority of BCS have HRQL similar to non-cancer controls after 2 years, subgroups of BCS continue to have low HRQL. Prediagnosis stress, comorbidities, and smoking are vulnerability factors for long-term, low HRQL in BCS.</p>
dc.identifier.submissionpathgsn_pp/145
dc.contributor.departmentGraduate School of Nursing
dc.source.pages2296-2304


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