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dc.contributor.authorde Wit, Anouk E.
dc.contributor.authorGiltay, Erik J.
dc.contributor.authorde Boer, Marrit K.
dc.contributor.authorNathan, Margo
dc.contributor.authorWiley, Aleta
dc.contributor.authorCrawford, Sybil L.
dc.contributor.authorJoffe, Hadine
dc.date2022-08-11T08:09:04.000
dc.date.accessioned2022-08-23T16:17:07Z
dc.date.available2022-08-23T16:17:07Z
dc.date.issued2021-04-01
dc.date.submitted2021-03-11
dc.identifier.citation<p>de Wit AE, Giltay EJ, de Boer MK, Nathan M, Wiley A, Crawford S, Joffe H. Predictors of irritability symptoms in mildly depressed perimenopausal women. Psychoneuroendocrinology. 2021 Jan 7;126:105128. doi: 10.1016/j.psyneuen.2021.105128. Epub ahead of print. PMID: 33493755. <a href="https://doi.org/10.1016/j.psyneuen.2021.105128">Link to article on publisher's site</a></p>
dc.identifier.issn0306-4530 (Linking)
dc.identifier.doi10.1016/j.psyneuen.2021.105128
dc.identifier.pmid33493755
dc.identifier.urihttp://hdl.handle.net/20.500.14038/34485
dc.description.abstractOBJECTIVE: Irritability is a highly burdensome complaint, commonly, but not universally, linked with depressive symptoms. While increased variability in estradiol has been associated with depressive symptoms during perimenopause, more insight is needed into reproductive hormone dynamics and other factors that predispose perimenopausal women to irritable mood. METHODS: Among 50 mildly depressed perimenopausal women (mean (SD) age 48.4 (3.9) years), severity of irritability symptoms (on Symptom Questionnaire Hostility subscale, range 0-23) was assessed weekly for eight weeks, concurrent with potential predictors. Associations between these were examined using generalized estimating equating models. RESULTS: Most women (82.0%) reported having moderate to severe irritability at least once. However, the severity of irritability was highly variable from week-to-week (between-subject mean coefficient of variation [CV] 72.9% and within-subject mean CV 63.7%). In multivariate analyses, less variable serum estradiol levels (standardized beta within-person CV -0.23 95%CI [-0.32, -0.14], p < 0.001), greater depression severity (0.45 [0.35, 0.56], p < 0.001), younger age (-0.23, [-0.28, -0.09], p < 0.001), and more frequent vasomotor symptoms (0.14 [0.05, 0.23], p=0.002) were associated with more irritability. Depression severity explained the largest portion of the variance in irritability, but still not more than 20.3%. Neither crude values, weekly change in, or variability of progesterone or FSH levels were associated with irritability. CONCLUSIONS: Irritability was highly prevalent among mildly depressed perimenopausal women. In contrast to depressive symptoms, decreased rather than increased variability in estradiol levels was associated with more irritability. This highlights that irritable mood can be disentangled from depressive symptoms in perimenopausal women and might be linked with different estradiol dynamics.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=33493755&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rights© 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectDepression
dc.subjectIrritability
dc.subjectPerimenopause
dc.subjectPredictors
dc.subjectReproductive hormones
dc.subjectEndocrinology
dc.subjectHormones, Hormone Substitutes, and Hormone Antagonists
dc.subjectPsychiatry and Psychology
dc.subjectReproductive and Urinary Physiology
dc.subjectWomen's Health
dc.titlePredictors of irritability symptoms in mildly depressed perimenopausal women
dc.typeJournal Article
dc.source.journaltitlePsychoneuroendocrinology
dc.source.volume126
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1163&amp;context=gsn_pp&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsn_pp/158
dc.identifier.contextkey22024462
refterms.dateFOA2022-08-23T16:17:07Z
html.description.abstract<p>OBJECTIVE: Irritability is a highly burdensome complaint, commonly, but not universally, linked with depressive symptoms. While increased variability in estradiol has been associated with depressive symptoms during perimenopause, more insight is needed into reproductive hormone dynamics and other factors that predispose perimenopausal women to irritable mood.</p> <p>METHODS: Among 50 mildly depressed perimenopausal women (mean (SD) age 48.4 (3.9) years), severity of irritability symptoms (on Symptom Questionnaire Hostility subscale, range 0-23) was assessed weekly for eight weeks, concurrent with potential predictors. Associations between these were examined using generalized estimating equating models.</p> <p>RESULTS: Most women (82.0%) reported having moderate to severe irritability at least once. However, the severity of irritability was highly variable from week-to-week (between-subject mean coefficient of variation [CV] 72.9% and within-subject mean CV 63.7%). In multivariate analyses, less variable serum estradiol levels (standardized beta within-person CV -0.23 95%CI [-0.32, -0.14], p < 0.001), greater depression severity (0.45 [0.35, 0.56], p < 0.001), younger age (-0.23, [-0.28, -0.09], p < 0.001), and more frequent vasomotor symptoms (0.14 [0.05, 0.23], p=0.002) were associated with more irritability. Depression severity explained the largest portion of the variance in irritability, but still not more than 20.3%. Neither crude values, weekly change in, or variability of progesterone or FSH levels were associated with irritability.</p> <p>CONCLUSIONS: Irritability was highly prevalent among mildly depressed perimenopausal women. In contrast to depressive symptoms, decreased rather than increased variability in estradiol levels was associated with more irritability. This highlights that irritable mood can be disentangled from depressive symptoms in perimenopausal women and might be linked with different estradiol dynamics.</p>
dc.identifier.submissionpathgsn_pp/158
dc.contributor.departmentGraduate School of Nursing
dc.contributor.departmentDept of Medicine, Division of Preventive and Behavioral Medicine
dc.source.pages105128


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© 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as © 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).