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    Quantitative Measures of Craniofacial Dysmorphology in a Family Study of Schizophrenia and Bipolar Illness

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    Authors
    Deutsch, Curtis K.
    Levy, Deborah L.
    Price, Selya F.R.
    Bodkin, J Alexander
    Boling, Lenore
    Coleman, Michael J.
    Johnson, Fred
    Lerbinger, Jan
    Matthysse, Steven
    Holzman, Philip S.
    UMass Chan Affiliations
    Eunice Kennedy Shriver Center
    Intellectual and Developmental Disabilities Research Center
    Document Type
    Journal Article
    Publication Date
    2015-03-20
    Keywords
    Developmental Biology
    Developmental Neuroscience
    Mental Disorders
    Neurosciences
    Psychiatric and Mental Health
    Psychiatry
    Psychiatry and Psychology
    
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    Link to Full Text
    http://dx.doi.org/10.1093/schbul/sbv014
    Abstract
    Several laboratories, including ours, have reported an overrepresentation of craniofacial (CF) anomalies in schizophrenia (SZ). How might this dysmorphology arise in a brain-based disorder? Because the brain and face derive from shared embryologic primordia and morphogenetic forces, maldevelopmental processes may result in both CF and brain dysmorphology. Our approach is 2-pronged. First, we have employed, for the first time in the study of psychiatric disorders, objective measures of CF morphology that utilize an extensive normative database, permitting computation of standardized scores for each subject. Second, we have rendered these findings biologically interpretable by adopting principles of embryology in the analysis of dysmorphology. Dependent measures in this investigation focused on derivatives of specific embryonic primordia and were contrasted among probands with psychotic disorders, their first-degree relatives, and normal controls (NC). Subject groups included patients with a diagnosis of SZ (N = 39) or bipolar (BP) disorder with psychotic features (N = 32), their clinically unaffected relatives (N = 82 and N = 41, respectively), and NC (N = 95) subjects. Anomalies involving derivatives of frontonasal and mandibular embryonic primordia showed a clear association with psychotic illness, as well as familial aggregation in relatives in both diagnostic groups. In contrast, one class of CF anomalies emerged only among SZ probands and their first-degree relatives: dysmorphology arising along the junction of the frontonasal and maxillary prominence derivatives, manifested as marked asymmetries. This class was not overrepresented among the BP patients nor among their relatives, indicating that this dysmorphology appears to be specific to SZ and not a generalized feature of psychosis. We discuss these findings in light of embryologic models that relate brain regions to specific CF areas.
    Source
    Deutsch CK, Levy DL, Price SF, Bodkin JA, Boling L, Coleman MJ, Johnson F, Lerbinger J, Matthysse S, Holzman PS. Quantitative Measures of Craniofacial Dysmorphology in a Family Study of Schizophrenia and Bipolar Illness. Schizophr Bull. 2015 Mar 20. pii: sbv014. [Epub ahead of print] PubMed PMID: 25795453. Link to article on publisher's site
    DOI
    10.1093/schbul/sbv014
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/34827
    PubMed ID
    25795453
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1093/schbul/sbv014
    Scopus Count
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