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    Chromatin accessibility and transcription factor binding at the PPARgamma2 promoter during adipogenesis is protein kinase a-dependent

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    Authors
    Xiao, Hengyi
    LeBlanc, Scott E.
    Wu, Qiong
    Konda, Silvana
    Salma, Nunciada
    Marfella, Concetta G. A.
    Ohkawa, Yasuyuki
    Imbalzano, Anthony N.
    UMass Chan Affiliations
    Department of Cell Biology
    Document Type
    Journal Article
    Publication Date
    2011-01-14
    Keywords
    Adipogenesis
    Chromatin
    Cyclic AMP-Dependent Protein Kinases
    PPAR gamma
    Promoter Regions, Genetic
    Transcription Factors
    Cell Biology
    
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    Link to Full Text
    http://dx.doi.org/10.1002/jcp.22308
    Abstract
    The nuclear hormone receptor peroxisome proliferator activated receptor gamma (PPARgamma) is a ligand-activated transcription factor that specifies formation of the adipocyte lineage. PPARgamma also serves as a primary target for the treatment of type 2 diabetes, illustrating both its medical relevance as well as the need to understand fundamental aspects of PPARgamma expression and function. Here, we characterize molecular changes that occur at the PPARgamma2 promoter within the first several hours of adipocyte differentiation in culture. Our results demonstrate that changes in chromatin accessibility at the PPARgamma2 promoter and occupancy of the promoter by the c-Fos transcription factor occur within an hour of the onset of differentiation, followed closely by the binding of the CCAAT/Enhancer Binding Protein beta (C/EBPbeta) transcription factor. All three events show a remarkable dependency on protein kinase A (PKA) activity. These results reflect novel requirements for the PKA signaling pathway and reinforce the importance of PKA function during the onset of adipocyte differentiation. J. Cell. Physiol. (c) 2010 Wiley-Liss, Inc.
    Source
    J Cell Physiol. 2011 Jan;226(1):86-93. Link to article on publisher's site
    DOI
    10.1002/jcp.22308
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/34849
    PubMed ID
    20625991
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1002/jcp.22308
    Scopus Count
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    UMass Chan Faculty and Researcher Publications

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