• Login
    View Item 
    •   Home
    • UMass Chan Faculty and Staff Research and Publications
    • UMass Chan Faculty and Researcher Publications
    • View Item
    •   Home
    • UMass Chan Faculty and Staff Research and Publications
    • UMass Chan Faculty and Researcher Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of eScholarship@UMassChanCommunitiesPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywordsThis CollectionPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywords

    My Account

    LoginRegister

    Help

    AboutSubmission GuidelinesData Deposit PolicySearchingAccessibilityTerms of UseWebsite Migration FAQ

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Chd2 interacts with H3.3 to determine myogenic cell fate

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Harada, Akihito
    Okada, Seiji
    Konno, Daijiro
    Odawara, Jun
    Yoshimi, Tomohiko
    Yoshimura, Saori
    Kumamaru, Hiromi
    Saiwai, Hirokazu
    Tsubota, Toshiaki
    Kurumizaka, Hitoshi
    Akashi, Koichi
    Tachibana, Taro
    Imbalzano, Anthony N.
    Ohkawa, Yasuyuki
    Show allShow less
    UMass Chan Affiliations
    Department of Cell and Developmental Biology
    Document Type
    Journal Article
    Publication Date
    2012-05-08
    Keywords
    Animals
    Cell Line
    DNA-Binding Proteins
    Gene Expression Regulation, Developmental
    Gene Knockdown Techniques
    Genetic Loci
    Histones
    Mice
    *Muscle Development
    MyoD Protein
    Transcriptional Activation
    Cell and Developmental Biology
    Cell Biology
    Show allShow less
    
    Metadata
    Show full item record
    Link to Full Text
    http://dx.doi.org/10.1038/emboj.2012.136
    Abstract
    Cell differentiation is mediated by lineage-determining transcription factors. We show that chromodomain helicase DNA-binding domain 2 (Chd2), a SNF2 chromatin remodelling enzyme family member, interacts with MyoD and myogenic gene regulatory sequences to specifically mark these loci via deposition of the histone variant H3.3 prior to cell differentiation. Directed and genome-wide analysis of endogenous H3.3 incorporation demonstrates that knockdown of Chd2 prevents H3.3 deposition at differentiation-dependent, but not housekeeping, genes and inhibits myogenic gene activation. The data indicate that MyoD determines cell fate and facilitates differentiation-dependent gene expression through Chd2-dependent deposition of H3.3 at myogenic loci prior to differentiation.
    Source
    EMBO J. 2012 May 8;31(13):2994-3007. doi: 10.1038/emboj.2012.136. Link to article on publisher's site
    DOI
    10.1038/emboj.2012.136
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/34856
    PubMed ID
    22569126
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1038/emboj.2012.136
    Scopus Count
    Collections
    UMass Chan Faculty and Researcher Publications

    entitlement

    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Lamar Soutter Library, UMass Chan Medical School | 55 Lake Avenue North | Worcester, MA 01655 USA
    Quick Guide | escholarship@umassmed.edu
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.