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    Mammalian SWI/SNF complexes promote MyoD-mediated muscle differentiation

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    Authors
    de la Serna, Ivana L.
    Carlson, Kerri A.
    Imbalzano, Anthony N.
    UMass Chan Affiliations
    Department of Cell Biology
    Document Type
    Journal Article
    Publication Date
    2001-02-15
    Keywords
    Adenosine Triphosphatases
    Animals
    Cell Differentiation
    DNA Helicases
    Gene Expression Regulation
    Mice
    Muscles
    MyoD Protein
    Nuclear Proteins
    Promoter Regions, Genetic
    Transcription Factors
    Cell Biology
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    Link to Full Text
    http://dx.doi.org/10.1038/84826
    Abstract
    Mammalian SWI/SNF complexes are ATP-dependent chromatin remodeling enzymes that have been implicated in the regulation of gene expression, cell-cycle control and oncogenesis. MyoD is a muscle-specific regulator able to induce myogenesis in numerous cell types. To ascertain the requirement for chromatin remodeling enzymes in cellular differentiation processes, we examined MyoD-mediated induction of muscle differentiation in fibroblasts expressing dominant-negative versions of the human brahma-related gene-1 (BRG1) or human brahma (BRM), the ATPase subunits of two distinct SWI/SNF enzymes. We find that induction of the myogenic phenotype is completely abrogated in the presence of the mutant enzymes. We further demonstrate that failure to induce muscle-specific gene expression correlates with inhibition of chromatin remodeling in the promoter region of an endogenous muscle-specific gene. Our results demonstrate that SWI/SNF enzymes promote MyoD-mediated muscle differentiation and indicate that these enzymes function by altering chromatin structure in promoter regions of endogenous, differentiation-specific loci.
    Source
    Nat Genet. 2001 Feb;27(2):187-90. Link to article on publisher's site
    DOI
    10.1038/84826
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/34868
    PubMed ID
    11175787
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1038/84826
    Scopus Count
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